HitPredict

Interactor 1: IKZF2 (Q9UKS7)
Zinc finger protein Helios (Ikaros family zinc finger protein 2)
Gene: IKZF2

Interactor 2: HDAC5 (Q9UQL6)
Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9)
Gene: HDAC5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	12015313
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 526 Hs			1 1122
+	Hs
		880848 IKZF2_HUMAN (1-526): 0: 696: 100.00		HDAC4_HUMAN (1-1101): 0: 653: 54.96
+	Hs
		1329659 IKZF4_HUMAN (9-524): 3.72e-165: 482: 54.22		HDAC5_HUMAN (1-1122): 0: 727: 100.00
+	Hs
		1033762 IKZF1_HUMAN (31-526): 2.39e-164: 478: 54.20		HDAC5_HUMAN (1-1122): 0: 727: 100.00
+	Hs
		1356578 IKZF3_HUMAN (10-524): 5.02e-160: 466: 46.52		HDAC5_HUMAN (1-1122): 0: 727: 100.00
+	Hs
		1038804 IKZF2_HUMAN (1-526): 0: 696: 100.00		HDAC1_HUMAN (673-1103): 1.54e-153: 468: 21.16
+	Hs
		1270517 IKZF2_HUMAN (1-526): 0: 696: 100.00		HDAC2_HUMAN (680-1113): 1.34e-153: 468: 21.68
+	Hs
		880822 IKZF4_HUMAN (9-524): 3.72e-165: 482: 54.22		HDAC4_HUMAN (1-1101): 0: 653: 54.96
+	Hs
		880715 IKZF1_HUMAN (31-526): 2.39e-164: 478: 54.20		HDAC4_HUMAN (1-1101): 0: 653: 54.96
+	Hs
		880849 IKZF3_HUMAN (10-524): 5.02e-160: 466: 46.52		HDAC4_HUMAN (1-1101): 0: 653: 54.96
+	Hs
		1260190 IKZF4_HUMAN (9-524): 3.72e-165: 482: 54.22		HDAC7_HUMAN (121-1122): 4.12e-159: 499: 40.82
+	Hs
		1033686 IKZF1_HUMAN (31-526): 2.39e-164: 478: 54.20		HDAC7_HUMAN (121-1122): 4.12e-159: 499: 40.82
+	Hs
		1260200 IKZF3_HUMAN (10-524): 5.02e-160: 466: 46.52		HDAC7_HUMAN (121-1122): 4.12e-159: 499: 40.82
+	Hs
		1270436 IKZF4_HUMAN (9-524): 3.72e-165: 482: 54.22		HDAC2_HUMAN (680-1113): 1.34e-153: 468: 21.68
+	Hs
		1033633 IKZF1_HUMAN (31-526): 2.39e-164: 478: 54.20		HDAC1_HUMAN (673-1103): 1.54e-153: 468: 21.16
+	Hs
		1033690 IKZF1_HUMAN (31-526): 2.39e-164: 478: 54.20		HDAC2_HUMAN (680-1113): 1.34e-153: 468: 21.68
+	Hs
		1038805 IKZF3_HUMAN (10-524): 5.02e-160: 466: 46.52		HDAC1_HUMAN (673-1103): 1.54e-153: 468: 21.16
+	Hs
		1270518 IKZF3_HUMAN (10-524): 5.02e-160: 466: 46.52		HDAC2_HUMAN (680-1113): 1.34e-153: 468: 21.68
+	Hs
		177285 IKZF1_HUMAN (31-526): 2.39e-164: 478: 54.20		HDAC3_HUMAN (679-1119): 5.97e-144: 441: 21.57
+	Mm
		140300 Q8C5P6_MOUSE (31-227): 4.19e-78: 248: 66.50		HDAC1_MOUSE (673-1103): 1.61e-153: 468: 21.16
+	Mm
		936415 Q8C5P6_MOUSE (31-227): 4.19e-78: 248: 66.50		HDAC2_MOUSE (680-1113): 4.65e-153: 467: 21.68