HitPredict

Interactor 1: FBXW2 (Q9UKT8)
F-box/WD repeat-containing protein 2 (F-box and WD-40 domain-containing protein 2) (Protein MD6)
Gene: FBXW2

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.879

Property	Details
Experiments	28090088, 28514442, 33961781
Identification Methods	affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	F-box-like~F-box-like, WD40~WD40
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 454 Hs			1 605
+	Hs
		1377151 FBW1A_HUMAN (23-313): 2.4e-60: 208: 17.97		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Mm
		1112902 FBW1A_MOUSE (23-309): 1.26e-59: 206: 17.88		FBW1A_MOUSE (1-605): 0: 547: 98.68
+	Hs
		1356371 FBW1A_HUMAN (23-313): 2.4e-60: 208: 17.97		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		1281468 FBXW2_HUMAN (1-454): 4.52e-104: 318: 100.00		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Sc
		431103 CDC4_YEAST (19-417): 2.5e-73: 247: 17.46		CDC4_YEAST (92-603): 9.8e-86: 285: 22.95
+	Hs
		1281292 FBXW7_HUMAN (32-264): 4.84e-57: 201: 21.85		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Dm
		1358859 FBXW7_DROME (9-451): 1.6e-100: 329: 22.88		WDS_DROME (457-605): 2.3e-37: 144: 25.16
+	Sp
		144899 POP2_SCHPO (122-384): 1.02e-46: 173: 21.12		POP1_SCHPO (110-605): 2.48e-85: 284: 22.59
+	Mm
		925836 LIS1_MOUSE (16-256): 1.38e-52: 183: 16.18		LIS1_MOUSE (174-494): 5.84e-74: 244: 21.37
+	Hs
		792935 LIS1_HUMAN (16-256): 1.66e-52: 183: 16.18		LIS1_HUMAN (174-494): 8.99e-74: 243: 21.37
+	Sp
		144895 POP2_SCHPO (122-384): 1.02e-46: 173: 21.12		POP2_SCHPO (227-482): 1.29e-47: 179: 17.59
+	Hs
		903418 FBXW7_HUMAN (32-264): 4.84e-57: 201: 21.85		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Hs
		792949 LIS1_HUMAN (16-256): 1.66e-52: 183: 16.18		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Hs
		209416 PLRG1_HUMAN (96-390): 6.55e-51: 181: 19.94		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Sc
		431134 CDC4_YEAST (19-417): 2.5e-73: 247: 17.46		MET30_YEAST (530-604): 1.34e-09: 63.1: 20.00
+	Ce
		1274778 SEL10_CAEEL (221-454): 1.88e-42: 159: 21.52		SEL10_CAEEL (461-604): 2.15e-32: 133: 27.21
+	Dm
		1363645 Q9VDE3_DROME (12-260): 2.83e-42: 158: 17.94		Q9VDE3_DROME (466-605): 2.66e-30: 126: 29.37
+	Hs
		245546 TBL1X_HUMAN (30-257): 4.63e-44: 164: 16.05		TBL1X_HUMAN (501-605): 3.8e-15: 80.4: 19.13
+	Hs
		245633 TBL1X_HUMAN (30-257): 4.63e-44: 164: 16.05		TBL1R_HUMAN (501-605): 3.85e-15: 80.4: 16.67
+	Hs
		245630 TBL1X_HUMAN (30-257): 4.63e-44: 164: 16.05		TBL1Y_HUMAN (501-605): 2.08e-14: 78.1: 20.00