HitPredict - High confidence protein-protein interactions

Interactor 1: AMFR (Q9UKV5)
E3 ubiquitin-protein ligase AMFR (EC 2.3.2.36) (Autocrine motility factor receptor) (AMF receptor) (RING finger protein 45) (gp78)
Gene: AMFR

Interactor 2: AMFR (Q9UKV5)
E3 ubiquitin-protein ligase AMFR (EC 2.3.2.36) (Autocrine motility factor receptor) (AMF receptor) (RING finger protein 45) (gp78)
Gene: AMFR

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.938

Property	Details
Experiments	11724934, 19223579, 23942235, 24810856, 17310145
Identification Methods	enzymatic study, affinity chromatography technology, anti tag coimmunoprecipitation, molecular sieving, x ray scattering
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	zf-RING_2~zf-RING_2
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0000209 - protein polyubiquitination GO:0004842 - ubiquitin-protein transferase activity GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane and 32 others more... GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006511 - ubiquitin-dependent protein catabolic process GO:0007165 - signal transduction GO:0007611 - learning or memory GO:0016020 - membrane GO:0016055 - Wnt signaling pathway GO:0030425 - dendrite GO:0030426 - growth cone GO:0030674 - protein-macromolecule adaptor activity GO:0030968 - endoplasmic reticulum unfolded protein response GO:0032991 - protein-containing complex GO:0034052 - positive regulation of plant-type hypersensitive response GO:0034450 - ubiquitin-ubiquitin ligase activity GO:0036503 - ERAD pathway GO:0036513 - Derlin-1 retrotranslocation complex GO:0038023 - signaling receptor activity GO:0038061 - non-canonical NF-kappaB signal transduction GO:0043025 - neuronal cell body GO:0043130 - ubiquitin binding GO:0044314 - protein K27-linked ubiquitination GO:0046872 - metal ion binding GO:0048471 - perinuclear region of cytoplasm GO:0051087 - protein-folding chaperone binding GO:0051865 - protein autoubiquitination GO:0061630 - ubiquitin protein ligase activity GO:0070936 - protein K48-linked ubiquitination GO:0090090 - negative regulation of canonical Wnt signaling pathway GO:1904288 - BAT3 complex binding GO:1990381 - ubiquitin-specific protease binding GO:2000638 - regulation of SREBP signaling pathway
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1	643
Hs

1	643

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Last updated: 15 Jul 2024