HitPredict

Interactor 1: AGO2 (Q9UKV8)
Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer)
Gene: AGO2

Interactor 2: AGO1 (Q9UL18)
Protein argonaute-1 (Argonaute1) (hAgo1) (Argonaute RISC catalytic component 1) (Eukaryotic translation initiation factor 2C 1) (eIF-2C 1) (eIF2C 1) (Putative RNA-binding protein Q99)
Gene: AGO1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.89 1.00 0.948

The method score is based on:

Property Details
Experiments 33961781, 35271311, 24086155, 24778252, 29395067, 16756390
Identification Methods affinity chromatography technology, proximity labelling technology, fluorescent resonance energy transfer, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains ArgoL1~ArgoL1, ArgoL1~ArgoL2, ArgoL1~ArgoN, ArgoL1~PAZ, ArgoL1~Piwi, ArgoL2~ArgoMid, ArgoL2~ArgoN, ArgoL2~PAZ, ArgoL2~Piwi, ArgoMid~ArgoMid, ArgoMid~Piwi, ArgoN~Piwi, PAZ~PAZ, PAZ~Piwi, Piwi~Piwi
Common GO terms GO:0000932 - P-body
GO:0000993 - RNA polymerase II complex binding
GO:0001046 - core promoter sequence-specific DNA binding
GO:0003723 - RNA binding
GO:0003725 - double-stranded RNA binding
and 16 others

more...
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 859
Hs

1 857
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Zm
+ Mm
+ Dr
+ Dm
+ Dm

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Last updated: 15 Jul 2024