HitPredict

Interactor 1: AGO2 (Q9UKV8)
Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer)
Gene: AGO2

Interactor 2: DICER (Q9UPY3)
Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI)
Gene: DICER1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.989

The method score is based on:

Property Details
Experiments 26496610, 29395067, 12526743, 33961781, 17932509, 34518544, 14749716, 19716330, 23143396, 16357216, 24778252, 19820710, 23636329, 19955415, 22484317, 25446899, 21858095, 23622242, 23741051
Identification Methods affinity chromatography technology, proximity labelling technology, pull down, two hybrid, molecular sieving, anti tag coimmunoprecipitation, electron microscopy, anti bait coimmunoprecipitation, coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains ArgoL1~PAZ, ArgoL2~PAZ, PAZ~PAZ, PAZ~Ribonuclease_3, PAZ~Piwi
Common GO terms GO:0003723 - RNA binding
GO:0003725 - double-stranded RNA binding
GO:0004521 - RNA endonuclease activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
and 11 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 859
Hs

1 1922
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+ Dm
+ Dm

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Last updated: 15 Jul 2024