HitPredict

Interactor 1: HECD1 (Q9ULT8)
E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1)
Gene: HECTD1

Interactor 2: MACF1 (Q9UPN3)
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)
Gene: MACF1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	35915203
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~EF-hand_7
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 2610 Hs			1 7388
+	Hs
		1350503 HECW2_HUMAN (1360-2609): 2.26e-127: 444: 14.40		MACF1_HUMAN (1-7388): 0: 2387: 100.00
+	Hs
		809199 HECD1_HUMAN (1-2610): 0: 2419: 100.00		UTRN_HUMAN (428-1437): 8.81e-11: 71.9: 13.98
+	Hs
		304018 UBR5_HUMAN (1985-2609): 1.07e-116: 418: 16.94		DESP_HUMAN (2737-3775): 9.21e-27: 124: 8.65
+	Hs
		551845 SMUF1_HUMAN (2220-2607): 1.5e-116: 391: 19.70		DESP_HUMAN (2737-3775): 9.21e-27: 124: 8.65
+	Hs
		304122 UBR5_HUMAN (1985-2609): 1.07e-116: 418: 16.94		SPTB2_HUMAN (6378-7134): 6.05e-11: 72.5: 13.80
+	Hs
		304012 UBR5_HUMAN (1985-2609): 1.07e-116: 418: 16.94		ACTN1_HUMAN (921-1398): 1.47e-10: 70.5: 9.07
+	Hs
		304161 UBR5_HUMAN (1985-2609): 1.07e-116: 418: 16.94		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Hs
		963426 SMUF1_HUMAN (2220-2607): 1.5e-116: 391: 19.70		SPTB2_HUMAN (6378-7134): 6.05e-11: 72.5: 13.80
+	Hs
		521619 SMUF1_HUMAN (2220-2607): 1.5e-116: 391: 19.70		ACTN1_HUMAN (921-1398): 1.47e-10: 70.5: 9.07
+	Hs
		1045530 SMUF1_HUMAN (2220-2607): 1.5e-116: 391: 19.70		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Mm
		103598 ANK3_MOUSE (8-1037): 1.34e-90: 331: 12.59		Q3UGX2_MOUSE (4327-6070): 9.91e-20: 101: 11.29
+	Mm
		103603 ANK3_MOUSE (8-1037): 1.34e-90: 331: 12.59		SPTB2_MOUSE (6378-7134): 3.94e-11: 72.8: 13.67
+	Mm
		82740 ANK3_MOUSE (8-1037): 1.34e-90: 331: 12.59		B9EKJ1_MOUSE (433-1344): 4.47e-09: 66.1: 13.69
+	Hs
		506803 ANK1_HUMAN (354-913): 1.43e-61: 237: 12.27		SPTB1_HUMAN (3013-4737): 1.1e-28: 131: 8.92
+	Hs
		556695 ANK1_HUMAN (354-913): 1.43e-61: 237: 12.27		SPTB2_HUMAN (6378-7134): 6.05e-11: 72.5: 13.80
+	Hs
		521548 UBE3C_HUMAN (2405-2610): 9.09e-23: 109: 32.37		ACTN1_HUMAN (921-1398): 1.47e-10: 70.5: 9.07
+	Mm
		1143711 HUWE1_MOUSE (2405-2609): 1.01e-18: 96.7: 33.33		SPTB2_MOUSE (6378-7134): 3.94e-11: 72.8: 13.67