Interactor 1: ASC (Q9ULZ3)
Apoptosis-associated speck-like protein containing a CARD (hASC) (Caspase recruitment domain-containing protein 5) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1)
Gene: PYCARD

Interactor 2: ASC (Q9ULZ3)
Apoptosis-associated speck-like protein containing a CARD (hASC) (Caspase recruitment domain-containing protein 5) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1)
Gene: PYCARD

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.977

The method score is based on:

Property Details
Experiments 25416956, 24407287, 28247911, 34407203, 35727133, 36050480, 30612879, 23209292, 19337385, 25006247, 24630722
Identification Methods two hybrid, affinity chromatography technology, fluorescent resonance energy transfer, pull down, two hybrid array, fluorescence polarization spectroscopy, electron microscopy, molecular sieving, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains CARD~CARD, PYRIN~PYRIN
Common GO terms GO:0000139 - Golgi membrane
GO:0001773 - myeloid dendritic cell activation
GO:0002020 - protease binding
GO:0002218 - activation of innate immune response
GO:0002221 - pattern recognition receptor signaling pathway
and 85 others

more...

Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 195
Hs

1 195
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Last updated: 15 Jul 2024