HitPredict

Interactor 1: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Interactor 2: JIP3 (Q9UPT6)
C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3)
Gene: MAPK8IP3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	14968112
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1620 Hs			1 1336
+	Hs
		164157 ALK_HUMAN (1-1620): 0: 1883: 100.00		ARHGA_HUMAN (913-1292): 8.49e-82: 297: 20.57
+	Hs
		725268 ALK_HUMAN (1-1620): 0: 1883: 100.00		MYH10_HUMAN (243-769): 2.9e-24: 113: 8.89
+	Hs
		725069 ALK_HUMAN (1-1620): 0: 1883: 100.00		MYH9_HUMAN (228-774): 4.87e-21: 102: 8.04
+	Hs
		229615 NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07		JIP4_HUMAN (6-1336): 0: 671: 54.25
+	Hs
		164095 FGFR1_HUMAN (952-1454): 2.04e-118: 395: 26.06		ARHGA_HUMAN (913-1292): 8.49e-82: 297: 20.57
+	Hs
		164126 NTRK2_HUMAN (1093-1375): 7.35e-64: 236: 41.44		ARHGA_HUMAN (913-1292): 8.49e-82: 297: 20.57
+	Hs
		164090 NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07		ARHGA_HUMAN (913-1292): 8.49e-82: 297: 20.57
+	Hs
		665595 EPHB2_HUMAN (938-1436): 2.19e-123: 416: 23.26		ROCK1_HUMAN (2-581): 2.57e-21: 103: 9.37
+	Hs
		665375 EPHA3_HUMAN (943-1427): 7.27e-120: 404: 25.87		MYH9_HUMAN (228-774): 4.87e-21: 102: 8.04
+	Hs
		507982 FGFR1_HUMAN (952-1454): 2.04e-118: 395: 26.06		ROCK1_HUMAN (2-581): 2.57e-21: 103: 9.37
+	Rn
		88668 INSR_RAT (973-1484): 1.45e-112: 392: 32.38		D3ZN37_RAT (276-702): 7.28e-17: 88.8: 8.67
+	Hs
		254442 FGFR1_HUMAN (952-1454): 2.04e-118: 395: 26.06		ROCK2_HUMAN (2-348): 1.31e-13: 78.3: 7.20
+	Hs
		609500 FGFR3_HUMAN (952-1449): 6.42e-121: 401: 26.31		AKAP9_HUMAN (45-563): 1.97e-11: 71.2: 13.56
+	Rn
		89022 INSR_RAT (973-1484): 1.45e-112: 392: 32.38		D4AE06_RAT (1-357): 7.01e-14: 79.1: 9.75
+	Hs
		972340 TIE2_HUMAN (954-1389): 7.66e-115: 393: 29.30		MYH14_HUMAN (80-569): 1.98e-11: 71.2: 13.69
+	Hs
		384385 NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07		MYH10_HUMAN (243-769): 2.9e-24: 113: 8.89
+	Hs
		384789 NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07		ROCK1_HUMAN (2-581): 2.57e-21: 103: 9.37
+	Hs
		384384 NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07		MYH9_HUMAN (228-774): 4.87e-21: 102: 8.04
+	Hs
		384210 NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07		DESP_HUMAN (27-706): 3.94e-16: 86.8: 11.43
+	Hs
		254431 NTRK1_HUMAN (1111-1392): 5.05e-62: 230: 42.07		ROCK2_HUMAN (2-348): 1.31e-13: 78.3: 7.20