HitPredict

Interactor 1: PRP19 (Q9UMS4)
Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor)
Gene: PRPF19

Interactor 2: PRP19 (Q9UMS4)
Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor)
Gene: PRPF19

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.73 1.00 0.856

The method score is based on:

Property Details
Experiments 20599946, 19641227, 16332694
Identification Methods affinity chromatography technology, two hybrid, pull down, fluorescent resonance energy transfer
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Prp19~Prp19, Prp19~U-box, U-box~U-box, WD40~WD40
Common GO terms GO:0000077 - DNA damage checkpoint signaling
GO:0000209 - protein polyubiquitination
GO:0000244 - spliceosomal tri-snRNP complex assembly
GO:0000245 - spliceosomal complex assembly
GO:0000398 - mRNA splicing, via spliceosome
and 22 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 504
Hs

1 504
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024