Interactor 1: CHIP (Q9UNE7)
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)
Gene: STUB1

Interactor 2: CHIP (Q9UNE7)
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)
Gene: STUB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.994

The method score is based on:

Property Details
Experiments 25258038, 25684577, 26330542, 26010904, 17426036, 28134249, 28757353, 29091030, 28396517, 28496195, 28852129, 23695783, 29317501, 31596601, 32723828, 34057440, 18485199, 35398354, 36027913, 36481767 and 12 others

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Identification Methods enzymatic study, pull down, affinity chromatography technology, protein complementation assay
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains ANAPC3~ANAPC3, ANAPC3~CHIP_TPR_N, CHIP_TPR_N~CHIP_TPR_N, CHIP_TPR_N~U-box, U-box~U-box
Common GO terms GO:0000151 - ubiquitin ligase complex
GO:0000165 - MAPK cascade
GO:0000209 - protein polyubiquitination
GO:0001664 - G protein-coupled receptor binding
GO:0002931 - response to ischemia
and 55 others

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Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 303
Hs

1 303
+ Mm
+ Mm
+ Ce
+ Dm
+ Hs
+ Mm
+ Hs
+ Ps
+ Hs
+ Hs
+ Rn
+ Mm
+ Hs
+ Mm
+ Hs
+ Dm
+ Hs

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Last updated: 15 Jul 2024