HitPredict

Interactor 1: CHIP (Q9UNE7)
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)
Gene: STUB1

Interactor 2: KLDC2 (Q9Y2U9)
Kelch domain-containing protein 2 (Hepatocellular carcinoma-associated antigen 33) (Host cell factor homolog LCP) (Host cell factor-like protein 1) (HCLP-1)
Gene: KLHDC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016567 - protein ubiquitination GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 303 Hs			1 406
+	Hs
		1290185 SGTB_HUMAN (70-177): 7.78e-10: 60.8: 18.52		KLDC2_HUMAN (1-406): 3.72e-107: 323: 100.00
+	Hs
		985640 CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00		Q05C05_HUMAN (5-251): 2.38e-36: 141: 17.78
+	Hs
		1159469 CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00		FBX42_HUMAN (212-366): 7.52e-22: 99.9: 25.00
+	Hs
		213507 SGTA_HUMAN (3-140): 2.4e-33: 126: 29.71		HCFC1_HUMAN (1-302): 6.46e-41: 157: 17.43
+	Hs
		985639 Q9BPW0_HUMAN (1-259): 2.98e-36: 137: 20.91		Q05C05_HUMAN (5-251): 2.38e-36: 141: 17.78
+	Hs
		1049268 WDTC1_HUMAN (21-272): 3.45e-30: 122: 18.82		KEAP1_HUMAN (226-406): 5.71e-30: 123: 15.76
+	Hs
		183087 KDM6A_HUMAN (25-206): 2.59e-10: 63.1: 13.02		HCFC1_HUMAN (1-302): 6.46e-41: 157: 17.43
+	Hs
		183181 KDM6A_HUMAN (25-206): 2.59e-10: 63.1: 13.02		HCFC2_HUMAN (5-251): 9.3e-34: 135: 17.22