Interactor 1: P3C2B (O00750)
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PI3K-C2-beta) (PtdIns-3-kinase C2 subunit beta) (EC 2.7.1.137) (EC 2.7.1.154) (C2-PI3K) (Phosphoinositide 3-kinase-C2-beta)
Gene: PIK3C2B
Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.91 | 0.60 | 0.741 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25402006, 24658140, 31959764, 11533253, 10805725, unassigned2173 |
| Identification Methods | two hybrid, protein complementation assay, affinity chromatography technology, pull down, anti bait coimmunoprecipitation, ubiquitin reconstruction, anti tag coimmunoprecipitation, competition binding, luminescence based mammalian interactome mapping |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005886 - plasma membrane |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
