HitPredict

Interactor 1: AP4E1 (Q9UPM8)
AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin)
Gene: AP4E1

Interactor 2: AP4B1 (Q9Y6B7)
AP-4 complex subunit beta-1 (AP-4 adaptor complex subunit beta) (Adaptor-related protein complex 4 subunit beta-1) (Beta subunit of AP-4) (Beta4-adaptin)
Gene: AP4B1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.86 1.00 0.928

The method score is based on:

Property Details
Experiments 26496610, 11409905, 10436028, 32073997, 33961781
Identification Methods affinity chromatography technology, two hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Adaptin_N~Adaptin_N
Common GO terms GO:0005802 - trans-Golgi network
GO:0006605 - protein targeting
GO:0006886 - intracellular protein transport
GO:0008104 - protein localization
GO:0016192 - vesicle-mediated transport
and 3 others

more...
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 1137
Hs

1 739
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024