HitPredict

Interactor 1: DYN3 (Q9UQ16)
Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin)
Gene: DNM3

Interactor 2: SNX9 (Q9Y5X1)
Sorting nexin-9 (SH3 and PX domain-containing protein 1) (Protein SDP1) (SH3 and PX domain-containing protein 3A)
Gene: SNX9

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	28514442, 33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~PX
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0006897 - endocytosis GO:0070062 - extracellular exosome GO:0098793 - presynapse
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 869 Hs			1 595
+	Hs
		840879 DYN2_HUMAN (1-869): 0: 1041: 79.21		SNX9_HUMAN (1-595): 5.31e-180: 523: 100.00
+	Hs
		2824 A0A0D9SFE4_HUMAN (1-869): 0: 1038: 77.96		SNX9_HUMAN (1-595): 5.31e-180: 523: 100.00
+	Hs
		983421 DYN1_HUMAN (1-852): 0: 1035: 78.56		SNX9_HUMAN (1-595): 5.31e-180: 523: 100.00
+	Hs
		1261052 DYN3_HUMAN (1-869): 0: 1080: 100.00		SNX33_HUMAN (1-595): 3.41e-135: 407: 34.73
+	Hs
		840772 DYN2_HUMAN (1-869): 0: 1041: 79.21		SNX33_HUMAN (1-595): 3.41e-135: 407: 34.73
+	Hs
		983396 DYN1_HUMAN (1-852): 0: 1035: 78.56		SNX33_HUMAN (1-595): 3.41e-135: 407: 34.73
+	Hs
		840797 DYN2_HUMAN (1-869): 0: 1041: 79.21		SNX18_HUMAN (1-519): 3.5e-123: 379: 33.09
+	Hs
		1040534 DYN3_HUMAN (1-869): 0: 1080: 100.00		SNX1_HUMAN (101-590): 7.37e-80: 263: 13.53
+	Hs
		240458 DYN3_HUMAN (1-869): 0: 1080: 100.00		SNX2_HUMAN (110-590): 5.95e-80: 263: 14.74
+	Hs
		240366 DYN2_HUMAN (1-869): 0: 1041: 79.21		SNX2_HUMAN (110-590): 5.95e-80: 263: 14.74
+	Ce
		760504 DYN1_CAEEL (3-815): 0: 947: 62.09		LST4_CAEEL (3-593): 9.29e-116: 357: 28.64
+	Hs
		1357821 DYN3_HUMAN (1-869): 0: 1080: 100.00		SNX5_HUMAN (247-592): 5.92e-62: 212: 13.54
+	Hs
		1357510 DYN3_HUMAN (1-869): 0: 1080: 100.00		SNX6_HUMAN (251-592): 1.17e-58: 203: 14.40
+	Ce
		105220 DYN1_CAEEL (3-815): 0: 947: 62.09		G5ECK4_CAEEL (1-589): 1.08e-49: 187: 13.13
+	Sc
		599475 VPS1_YEAST (7-745): 0: 605: 34.31		MVP1_YEAST (104-569): 1.35e-53: 192: 15.76