HitPredict

Interactor 1: AURKC (Q9UQB9)
Aurora kinase C (EC 2.7.11.1) (Aurora 3) (Aurora/IPL1-related kinase 3) (ARK-3) (Aurora-related kinase 3) (Aurora/IPL1/Eg2 protein 2) (Serine/threonine-protein kinase 13) (Serine/threonine-protein kinase aurora-C)
Gene: AURKC

Interactor 2: MYH4 (Q9Y623)
Myosin-4 (Myosin heavy chain 2b) (MyHC-2b) (Myosin heavy chain 4) (Myosin heavy chain IIb) (MyHC-IIb) (Myosin heavy chain, skeletal muscle, fetal)
Gene: MYH4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 309 Hs			1 1939
+	Hs
		610802 KAPCB_HUMAN (6-308): 7.39e-133: 382: 28.80		MYH4_HUMAN (1-1939): 0: 1211: 100.00
+	Hs
		522582 AURKC_HUMAN (1-309): 6.63e-134: 383: 100.00		MYH1_HUMAN (1-1939): 0: 1207: 94.07
+	Hs
		522538 KAPCB_HUMAN (6-308): 7.39e-133: 382: 28.80		MYH1_HUMAN (1-1939): 0: 1207: 94.07
+	Hs
		610795 KAPCB_HUMAN (6-308): 7.39e-133: 382: 28.80		MYH2_HUMAN (1-1939): 0: 1187: 91.50
+	Hs
		528359 KAPCB_HUMAN (6-308): 7.39e-133: 382: 28.80		MYH6_HUMAN (3-1939): 0: 1179: 80.30
+	Hs
		522653 AURKC_HUMAN (1-309): 6.63e-134: 383: 100.00		MYH7_HUMAN (717-1818): 1.08e-65: 249: 16.17
+	Hs
		681696 AKT1_HUMAN (5-309): 8.7e-134: 389: 29.47		MYH9_HUMAN (985-1939): 1.02e-61: 236: 17.93
+	Hs
		724962 AURKB_HUMAN (3-305): 2.39e-134: 386: 76.39		MYH9_HUMAN (985-1939): 1.02e-61: 236: 17.93
+	Hs
		568567 KAPCA_HUMAN (6-308): 1.57e-133: 384: 29.75		MYH9_HUMAN (985-1939): 1.02e-61: 236: 17.93
+	Hs
		728503 AURKB_HUMAN (3-305): 2.39e-134: 386: 76.39		MYH11_HUMAN (724-1785): 1.11e-60: 233: 18.21
+	Hs
		728527 AURKC_HUMAN (1-309): 6.63e-134: 383: 100.00		MYH11_HUMAN (724-1785): 1.11e-60: 233: 18.21
+	Hs
		528433 AURKC_HUMAN (1-309): 6.63e-134: 383: 100.00		MYH8_HUMAN (985-1939): 2.26e-59: 229: 17.81
+	Hs
		725220 AURKB_HUMAN (3-305): 2.39e-134: 386: 76.39		MYH10_HUMAN (725-1631): 1.79e-43: 177: 14.97
+	Hs
		568568 KAPCA_HUMAN (6-308): 1.57e-133: 384: 29.75		MYH10_HUMAN (725-1631): 1.79e-43: 177: 14.97
+	Hs
		1189785 AURKB_HUMAN (3-305): 2.39e-134: 386: 76.39		MYH14_HUMAN (782-1411): 5.92e-24: 113: 15.12