HitPredict

Interactor 1: CSN4 (Q9V345)
COP9 signalosome complex subunit 4 (Dch4) (Signalosome subunit 4)
Gene: CSN4

Interactor 2: CSN7 (Q9V4S8)
COP9 signalosome complex subunit 7 (Dch7) (Signalosome subunit 7)
Gene: CSN7

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.885

Property	Details
Experiments	10531038, 25119050, 37061542, 22036573
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	CSN4_RPN5_eIF3a~CSN7a_helixI, CSN4_RPN5_eIF3a~PCI, PCI~PCI
Common GO terms	GO:0000338 - protein deneddylation GO:0007281 - germ cell development GO:0008180 - COP9 signalosome GO:0036099 - female germ-line stem cell population maintenance GO:0048140 - male germ-line cyst encapsulation and 1 others more... GO:0050821 - protein stabilization
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 407 Dm			1 278
+	Hs
		1311900 CSN4_HUMAN (9-402): 1.05e-121: 360: 72.34		CSN7B_HUMAN (6-270): 3.82e-93: 277: 43.77
+	Hs
		1311913 CSN4_HUMAN (9-402): 1.05e-121: 360: 72.34		CSN7A_HUMAN (21-271): 3.34e-84: 255: 43.36
+	Dm
		1277031 CSN2_DROME (3-388): 3.07e-85: 268: 14.14		CSN7_DROME (1-278): 2.02e-108: 317: 100.00
+	At
		1226053 CSN4_ARATH (18-398): 3.91e-97: 297: 46.80		CSN7_ARATH (14-269): 2.33e-92: 275: 33.07
+	At
		1278364 PSD11_ARATH (8-403): 1.9e-89: 278: 14.74		CSN7_ARATH (14-269): 2.33e-92: 275: 33.07
+	Hs
		897312 CSN2_HUMAN (1-388): 1.33e-87: 274: 13.33		CSN7B_HUMAN (6-270): 3.82e-93: 277: 43.77
+	Hs
		897324 CSN2_HUMAN (1-388): 1.33e-87: 274: 13.33		CSN7A_HUMAN (21-271): 3.34e-84: 255: 43.36
+	Mm
		897342 CSN2_MOUSE (1-388): 1.33e-87: 274: 13.33		CSN7A_MOUSE (21-271): 3.96e-83: 252: 43.36
+	Hs
		122044 PSD12_HUMAN (29-399): 1.89e-87: 274: 19.19		EIF3M_HUMAN (9-196): 6.14e-61: 198: 22.05
+	Hs
		121872 PSD11_HUMAN (4-402): 3.63e-89: 277: 13.48		PSD13_HUMAN (25-199): 7.44e-58: 191: 16.76
+	Hs
		122105 PSD12_HUMAN (29-399): 1.89e-87: 274: 19.19		PSD13_HUMAN (25-199): 7.44e-58: 191: 16.76
+	Dm
		1180705 PSD11_DROME (10-402): 6.43e-91: 282: 13.68		Q7KMP8_DROME (32-199): 2.9e-54: 181: 19.10
+	Ce
		1276132 CSN4_CAEEL (7-406): 2.16e-92: 285: 35.19		EIF3M_CAEEL (10-224): 1.22e-50: 172: 22.87
+	An
		961360 CSN4_EMENI (16-399): 2.38e-86: 270: 36.52		CSN7_EMENI (10-237): 1.39e-51: 173: 27.31
+	Ce
		136315 CSN2_CAEEL (1-372): 8.41e-83: 263: 12.73		EIF3M_CAEEL (10-224): 1.22e-50: 172: 22.87
+	An
		961357 CSN2_EMENI (1-393): 6.92e-82: 261: 15.44		CSN7_EMENI (10-237): 1.39e-51: 173: 27.31
+	Dm
		1180999 Q9V3Z4_DROME (30-399): 4.45e-78: 251: 18.31		Q7KMP8_DROME (32-199): 2.9e-54: 181: 19.10
+	Sc
		978512 RPN6_YEAST (13-400): 3.48e-75: 241: 12.41		RPN9_YEAST (20-199): 1.93e-50: 172: 16.84
+	Sc
		978511 RPN5_YEAST (32-399): 5.8e-72: 234: 19.17		RPN9_YEAST (20-199): 1.93e-50: 172: 16.84