HitPredict

Interactor 1: UBE2C (O00762)
Ubiquitin-conjugating enzyme E2 C (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme C) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme C) (UbcH10) (Ubiquitin carrier protein C) (Ubiquitin-protein ligase C)
Gene: UBE2C

Interactor 2: PCGF3 (Q3KNV8)
Polycomb group RING finger protein 3 (RING finger protein 3A)
Gene: PCGF3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	19549727
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 179 Hs			1 242
+	Hs
		717650 UB2D2_HUMAN (31-176): 3.22e-80: 236: 34.93		BMI1_HUMAN (3-238): 2.96e-60: 194: 33.76
+	Hs
		584923 UB2D2_HUMAN (31-176): 3.22e-80: 236: 34.93		RO52_HUMAN (2-241): 3.02e-47: 164: 15.56
+	Hs
		1318719 UB2D4_HUMAN (31-176): 1.99e-80: 236: 37.67		TRIM5_HUMAN (2-238): 5.65e-41: 148: 16.60
+	Hs
		1285831 UB2D4_HUMAN (31-176): 1.99e-80: 236: 37.67		TRI43_HUMAN (11-242): 4.59e-39: 142: 15.98
+	Hs
		919816 UB2D2_HUMAN (31-176): 3.22e-80: 236: 34.93		TRI43_HUMAN (11-242): 4.59e-39: 142: 15.98
+	Hs
		1304199 UB2D4_HUMAN (31-176): 1.99e-80: 236: 37.67		RING2_HUMAN (2-237): 3.42e-36: 132: 18.00
+	Hs
		919836 UB2D2_HUMAN (31-176): 3.22e-80: 236: 34.93		RING2_HUMAN (2-237): 3.42e-36: 132: 18.00
+	Mm
		919925 UB2D2_MOUSE (31-176): 3.22e-80: 236: 34.93		TRI17_MOUSE (2-241): 2.34e-35: 132: 15.61
+	Hs
		919711 UB2D2_HUMAN (31-176): 3.22e-80: 236: 34.93		RING1_HUMAN (3-172): 3.16e-35: 131: 20.81
+	Hs
		988038 UB2D4_HUMAN (31-176): 1.99e-80: 236: 37.67		RING1_HUMAN (3-172): 3.16e-35: 131: 20.81
+	Hs
		1336390 UB2D4_HUMAN (31-176): 1.99e-80: 236: 37.67		TRI39_HUMAN (8-208): 5.07e-33: 126: 15.94
+	Hs
		1377469 UB2D4_HUMAN (31-176): 1.99e-80: 236: 37.67		TRI17_HUMAN (2-238): 4.57e-33: 126: 15.47
+	Hs
		919822 UB2D2_HUMAN (31-176): 3.22e-80: 236: 34.93		TRI11_HUMAN (2-191): 4.75e-32: 123: 14.36
+	Hs
		1290127 UB2D4_HUMAN (31-176): 1.99e-80: 236: 37.67		CHFR_HUMAN (3-181): 2.94e-31: 122: 16.76
+	Hs
		536779 UB2D2_HUMAN (31-176): 3.22e-80: 236: 34.93		TRI27_HUMAN (2-237): 2.45e-31: 122: 12.06
+	Hs
		537142 UB2D4_HUMAN (31-176): 1.99e-80: 236: 37.67		TRI27_HUMAN (2-237): 2.45e-31: 122: 12.06
+	Hs
		919712 UB2D2_HUMAN (31-176): 3.22e-80: 236: 34.93		TRI26_HUMAN (2-208): 2.66e-31: 122: 15.28
+	Hs
		919820 UB2D2_HUMAN (31-176): 3.22e-80: 236: 34.93		CHFR_HUMAN (3-181): 2.94e-31: 122: 16.76
+	Hs
		1354526 UB2D4_HUMAN (31-176): 1.99e-80: 236: 37.67		TRI10_HUMAN (2-195): 1.19e-28: 114: 18.87
+	Hs
		919794 UB2D2_HUMAN (31-176): 3.22e-80: 236: 34.93		COP1_HUMAN (17-94): 2.22e-10: 62.2: 25.64