HitPredict

Interactor 1: AXN (Q9V407)
Axin (Axis inhibition protein) (d-Axin) (dAxin)
Gene: AXN

Interactor 2: Q9Y1T2 (Q9Y1T2)
Adenomatous polyposis coli 2 (Adenomatous polyposis coli 2, isoform C) (Epithelial adenomatous polyposis coli)
Gene: Apc2

Species: Drosophila melanogaster

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.961

The method score is based on:

Property	Details
Experiments	21471006, 26393419, 26975665, 29408853, 21772251, 26446838, 27068743, 31189665
Identification Methods	affinity chromatography technology, two hybrid, protein complementation assay, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	Arm~Axin_b-cat_bind
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007367 - segment polarity determination GO:0008013 - beta-catenin binding GO:0016055 - Wnt signaling pathway and 6 others more... GO:0030707 - follicle cell of egg chamber development GO:0030877 - beta-catenin destruction complex GO:0032436 - positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0035293 - chitin-based larval cuticle pattern formation GO:0060090 - molecular adaptor activity GO:0090090 - negative regulation of canonical Wnt signaling pathway
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	745
Dm

1	1067

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024