HitPredict

Interactor 1: THIO2 (Q9V429)
Thioredoxin-2 (DmTrx-2)
Gene: Trx-2

Interactor 2: Q9W022 (Q9W022)
GEO01508p1 (RE49388p)
Gene: DmelCG8993

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22036573
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Thioredoxin~Thioredoxin
Common GO terms	GO:0015035 - protein-disulfide reductase activity GO:0045454 - cell redox homeostasis
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 106 Dm			1 142
+	Ss
		852760 THIO_SYNY3 (6-106): 1.93e-35: 118: 33.33		THIO_SYNY3 (33-138): 2e-39: 130: 27.36
+	Sc
		630629 TRX3_YEAST (2-103): 9.8e-35: 117: 39.22		TRX3_YEAST (34-126): 2.5e-36: 122: 27.96
+	Sc
		606189 TRX1_YEAST (1-105): 3.4e-36: 120: 42.86		TRX2_YEAST (34-138): 6.89e-35: 118: 35.24
+	Sc
		611706 TRX2_YEAST (1-106): 3.86e-36: 120: 44.34		TRX2_YEAST (34-138): 6.89e-35: 118: 35.24
+	Zm
		1125562 Q5EUD7_MAIZE (3-103): 5.04e-31: 114: 21.91		Q5EUD7_MAIZE (31-135): 5.84e-32: 118: 25.93
+	Hs
		671819 PDIA3_HUMAN (3-104): 7.47e-26: 101: 24.30		PDIA6_HUMAN (35-140): 1.72e-33: 123: 24.30
+	Hs
		531837 PDIA4_HUMAN (3-105): 5.27e-25: 99.4: 22.02		PDIA6_HUMAN (35-140): 1.72e-33: 123: 24.30
+	Hs
		671722 PDIA3_HUMAN (3-104): 7.47e-26: 101: 24.30		PDIA3_HUMAN (1-138): 9.89e-32: 119: 19.72
+	Hs
		531739 PDIA3_HUMAN (3-104): 7.47e-26: 101: 24.30		PDIA4_HUMAN (35-140): 2.92e-30: 115: 28.44
+	Hs
		531910 PDIA4_HUMAN (3-105): 5.27e-25: 99.4: 22.02		TXND5_HUMAN (55-138): 7.38e-30: 113: 26.14
+	Rn
		751960 PDIA4_RAT (3-105): 6.97e-23: 93.2: 22.02		PDIA4_RAT (2-138): 4.38e-28: 109: 18.31
+	Ss
		852837 THIO1_SYNY3 (13-92): 5.11e-18: 74.3: 38.75		THIO1_SYNY3 (40-124): 3.32e-37: 124: 34.12
+	Sp
		145835 TRX1_SCHPO (1-106): 2.35e-34: 115: 48.11		TRX1_SCHPO (36-123): 2.84e-13: 63.2: 35.23