HitPredict

Interactor 1: SMUF1 (Q9V853)
E3 ubiquitin-protein ligase Smurf1 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase Smurf1) (Lethal with a checkpoint kinase protein) (SMAD ubiquitination regulatory factor 1 homolog) (DSmurf)
Gene: Smurf

Interactor 2: Q9VGU4 (Q9VGU4)
FI02822p (Leash)
Gene: Leash

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	38270169
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1061 Dm			1 520
+	Dm
		1249317 SMUF1_DROME (1-1061): 0: 838: 100.00		Q8SYU5_DROME (3-475): 2.07e-100: 312: 23.41
+	Hs
		1299631 NED4L_HUMAN (9-1059): 0: 718: 27.34		TXNIP_HUMAN (3-409): 4.2e-89: 280: 17.12
+	Hs
		1285052 NED4L_HUMAN (9-1059): 0: 718: 27.34		ARRD3_HUMAN (4-392): 6.62e-88: 278: 19.52
+	Hs
		1252808 NED4L_HUMAN (9-1059): 0: 718: 27.34		ARRD2_HUMAN (4-379): 6.65e-79: 254: 18.00
+	Hs
		1241907 NED4L_HUMAN (9-1059): 0: 718: 27.34		ARRD4_HUMAN (4-375): 1.07e-76: 249: 19.17
+	Hs
		1234602 NED4L_HUMAN (9-1059): 0: 718: 27.34		ARRD1_HUMAN (6-455): 1.64e-74: 243: 19.82
+	Hs
		808216 NEDD4_HUMAN (83-1059): 0: 640: 25.65		ARRD3_HUMAN (4-392): 6.62e-88: 278: 19.52
+	Hs
		685841 NEDD4_HUMAN (83-1059): 0: 640: 25.65		ARRB2_HUMAN (11-349): 2.61e-78: 253: 16.62
+	Hs
		808046 NEDD4_HUMAN (83-1059): 0: 640: 25.65		ARRB1_HUMAN (21-327): 9.76e-77: 249: 15.95
+	Hs
		808187 NEDD4_HUMAN (83-1059): 0: 640: 25.65		ARRD1_HUMAN (6-455): 1.64e-74: 243: 19.82
+	Dm
		89902 D5SHR3_DROME (638-1061): 6.12e-175: 520: 42.33		Q9VGU4_DROME (1-520): 1.72e-116: 355: 100.00
+	Hs
		1192211 HUWE1_HUMAN (360-1060): 2.21e-169: 555: 27.27		TXNIP_HUMAN (3-409): 4.2e-89: 280: 17.12
+	Dm
		89895 D5SHR3_DROME (638-1061): 6.12e-175: 520: 42.33		Q8SYU5_DROME (3-475): 2.07e-100: 312: 23.41
+	Dm
		1249359 Q9W325_DROME (641-1061): 1.29e-172: 514: 42.62		Q8SYU5_DROME (3-475): 2.07e-100: 312: 23.41
+	Dm
		89904 D5SHR3_DROME (638-1061): 6.12e-175: 520: 42.33		Q9VI00_DROME (1-442): 6.46e-97: 302: 15.44
+	Dm
		89897 D5SHR3_DROME (638-1061): 6.12e-175: 520: 42.33		Q9I7L0_DROME (5-436): 3.17e-93: 292: 23.57
+	Hs
		1192131 HUWE1_HUMAN (360-1060): 2.21e-169: 555: 27.27		ARRD2_HUMAN (4-379): 6.65e-79: 254: 18.00
+	Dm
		1337204 Q9W325_DROME (641-1061): 1.29e-172: 514: 42.62		Q9I7L0_DROME (5-436): 3.17e-93: 292: 23.57
+	Hs
		1192130 HUWE1_HUMAN (360-1060): 2.21e-169: 555: 27.27		ARRD4_HUMAN (4-375): 1.07e-76: 249: 19.17
+	Dm
		89903 D5SHR3_DROME (638-1061): 6.12e-175: 520: 42.33		Q9VHZ7_DROME (1-315): 7.13e-81: 262: 22.57