HitPredict

Interactor 1: Q9V9R2 (Q9V9R2)
Cullin 2, isoform A (Cullin 2, isoform B) (LD36177p)
Gene: Cul2

Interactor 2: RBX1A (Q9W5E1)
RING-box protein 1A (Regulator of cullins 1a) (dRbx1)
Gene: Roc1a

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	18698375, 15331761
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~zf-rbx1, Cullin_Nedd8~zf-rbx1
Common GO terms	GO:0016032 - viral process GO:0016567 - protein ubiquitination GO:0019005 - SCF ubiquitin ligase complex GO:0031462 - Cul2-RING ubiquitin ligase complex GO:0032436 - positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 753 Dm			1 108
+	Mm
		921499 CUL4A_MOUSE (4-753): 0: 760: 24.31		RBX1_MOUSE (1-108): 2.41e-46: 146: 86.11
+	Hs
		921255 CUL4B_HUMAN (4-753): 0: 754: 25.49		RBX1_HUMAN (1-108): 2.41e-46: 146: 86.11
+	Mm
		56790 CUL4B_MOUSE (4-753): 0: 753: 25.36		RBX1_MOUSE (1-108): 2.41e-46: 146: 86.11
+	Hs
		921252 CUL2_HUMAN (1-753): 0: 753: 49.61		RBX1_HUMAN (1-108): 2.41e-46: 146: 86.11
+	Hs
		921254 CUL4A_HUMAN (4-753): 0: 750: 24.57		RBX1_HUMAN (1-108): 2.41e-46: 146: 86.11
+	At
		1275966 CUL3A_ARATH (3-753): 0: 751: 25.33		RBX1A_ARATH (17-108): 5.76e-43: 138: 92.39
+	Hs
		921253 CUL3_HUMAN (1-753): 0: 737: 24.37		RBX1_HUMAN (1-108): 2.41e-46: 146: 86.11
+	Hs
		921251 CUL1_HUMAN (6-753): 0: 732: 33.76		RBX1_HUMAN (1-108): 2.41e-46: 146: 86.11
+	Mm
		921509 CUL1_MOUSE (6-753): 0: 732: 33.76		RBX1_MOUSE (1-108): 2.41e-46: 146: 86.11
+	At
		1275962 CUL3B_ARATH (3-753): 0: 736: 25.72		RBX1A_ARATH (17-108): 5.76e-43: 138: 92.39
+	Dm
		1124381 Q5BI50_DROME (4-753): 0: 714: 25.46		RBX1A_DROME (1-108): 3.28e-49: 153: 100.00
+	Dm
		1213855 Q8IP45_DROME (2-753): 0: 714: 23.21		RBX1A_DROME (1-108): 3.28e-49: 153: 100.00
+	Mm
		1111822 CUL4A_MOUSE (4-753): 0: 760: 24.31		RBX2_MOUSE (20-107): 2.4e-30: 106: 50.00
+	Hs
		1043627 CUL4B_HUMAN (4-753): 0: 754: 25.49		RBX2_HUMAN (20-107): 2.25e-30: 106: 50.00
+	Hs
		1041486 CUL2_HUMAN (1-753): 0: 753: 49.61		RBX2_HUMAN (20-107): 2.25e-30: 106: 50.00
+	Hs
		1043275 CUL4A_HUMAN (4-753): 0: 750: 24.57		RBX2_HUMAN (20-107): 2.25e-30: 106: 50.00
+	Dm
		1213836 Q8IP45_DROME (2-753): 0: 714: 23.21		RBX1B_DROME (1-107): 5.67e-41: 132: 61.68
+	Hs
		1042735 CUL3_HUMAN (1-753): 0: 737: 24.37		RBX2_HUMAN (20-107): 2.25e-30: 106: 50.00
+	Hs
		1041242 CUL1_HUMAN (6-753): 0: 732: 33.76		RBX2_HUMAN (20-107): 2.25e-30: 106: 50.00
+	Dm
		1360493 Q9V9R2_DROME (1-753): 0: 763: 100.00		Q9VGI6_DROME (36-102): 9.55e-11: 59: 28.36