HitPredict

Interactor 1: RING1 (Q9VB08)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RING1) (Sex comb extra protein) (dRING protein) (dRING1)
Gene: Sce

Interactor 2: Q9W0B8 (Q9W0B8)
Coatomer subunit alpha
Gene: alphaCOP

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.50	0.464

Property	Details
Experiments	14605208
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 435 Dm			1 1234
+	Hs
		749273 BRCA1_HUMAN (31-391): 1.09e-52: 192: 13.68		COPA_HUMAN (1-1234): 0: 1179: 70.54
+	Hs
		863528 RING2_HUMAN (198-434): 9.74e-49: 171: 28.00		COPA_HUMAN (1-1234): 0: 1179: 70.54
+	Hs
		725375 BRCA1_HUMAN (31-391): 1.09e-52: 192: 13.68		COPB2_HUMAN (1-911): 2.99e-170: 529: 21.74
+	Hs
		725534 RING2_HUMAN (198-434): 9.74e-49: 171: 28.00		COPB2_HUMAN (1-911): 2.99e-170: 529: 21.74
+	Hs
		749427 BRCA1_HUMAN (31-391): 1.09e-52: 192: 13.68		TBL3_HUMAN (106-800): 3.8e-60: 224: 12.79
+	Hs
		903159 RING1_HUMAN (9-434): 1.73e-78: 250: 34.98		WDR5_HUMAN (359-613): 7.98e-32: 129: 11.55
+	Hs
		749312 BRCA1_HUMAN (31-391): 1.09e-52: 192: 13.68		WDR5_HUMAN (359-613): 7.98e-32: 129: 11.55
+	Hs
		903455 RING2_HUMAN (198-434): 9.74e-49: 171: 28.00		WDR5_HUMAN (359-613): 7.98e-32: 129: 11.55
+	Mm
		903677 RING2_MOUSE (198-434): 6.67e-49: 171: 28.00		WDR5_MOUSE (359-613): 7.98e-32: 129: 11.55
+	Hs
		717626 BMI1_HUMAN (29-324): 2e-47: 167: 12.73		WDR5_HUMAN (359-613): 7.98e-32: 129: 11.55
+	Hs
		903462 BARD1_HUMAN (5-386): 3.77e-33: 134: 10.43		WDR5_HUMAN (359-613): 7.98e-32: 129: 11.55
+	Hs
		903492 PCGF6_HUMAN (21-160): 1.24e-34: 133: 22.38		WDR5_HUMAN (359-613): 7.98e-32: 129: 11.55