HitPredict

Interactor 1: RING1 (Q9VB08)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RING1) (Sex comb extra protein) (dRING protein) (dRING1)
Gene: Sce

Interactor 2: Q9W215 (Q9W215)
GEO03726p1 (LD18758p) (Ring and YY1 binding protein, isoform A) (Ring and YY1 binding protein, isoform B)
Gene: RYBP

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.867

Property	Details
Experiments	25415640, 18562658, 25242320, 36070387
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RAWUL~YAF2_RYBP
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 435 Dm			1 150
+	Hs
		987989 RING1_HUMAN (9-434): 1.73e-78: 250: 34.98		YAF2_HUMAN (1-129): 1.37e-49: 158: 48.87
+	Dm
		627173 SUZ2_DROME (25-351): 4.29e-50: 184: 13.02		Q9W215_DROME (1-150): 7.35e-59: 181: 100.00
+	Mm
		193411 RING1_MOUSE (9-434): 2.32e-80: 255: 35.68		RYBP_MOUSE (1-129): 2.64e-29: 108: 38.51
+	Hs
		987991 RING1_HUMAN (9-434): 1.73e-78: 250: 34.98		RYBP_HUMAN (1-129): 3.89e-29: 108: 38.51
+	Mm
		1307837 RING2_MOUSE (198-434): 6.67e-49: 171: 28.00		YAF2_MOUSE (1-128): 1.51e-53: 168: 49.24
+	Hs
		718409 PCGF2_HUMAN (29-363): 3.49e-50: 175: 12.57		YAF2_HUMAN (1-129): 1.37e-49: 158: 48.87
+	Hs
		1222214 RING2_HUMAN (198-434): 9.74e-49: 171: 28.00		YAF2_HUMAN (1-129): 1.37e-49: 158: 48.87
+	Hs
		718000 BMI1_HUMAN (29-324): 2e-47: 167: 12.73		YAF2_HUMAN (1-129): 1.37e-49: 158: 48.87
+	Hs
		1222219 PCGF6_HUMAN (21-160): 1.24e-34: 133: 22.38		YAF2_HUMAN (1-129): 1.37e-49: 158: 48.87
+	Hs
		718410 PCGF2_HUMAN (29-363): 3.49e-50: 175: 12.57		RYBP_HUMAN (1-129): 3.89e-29: 108: 38.51
+	Hs
		1108516 PCGF3_HUMAN (34-211): 2.54e-32: 124: 18.68		YAF2_HUMAN (1-129): 1.37e-49: 158: 48.87
+	Mm
		1208123 RING2_MOUSE (198-434): 6.67e-49: 171: 28.00		RYBP_MOUSE (1-129): 2.64e-29: 108: 38.51
+	Hs
		1233162 RING2_HUMAN (198-434): 9.74e-49: 171: 28.00		RYBP_HUMAN (1-129): 3.89e-29: 108: 38.51
+	Mm
		620789 PCGF2_MOUSE (29-363): 8.35e-49: 171: 12.87		RYBP_MOUSE (1-129): 2.64e-29: 108: 38.51
+	Hs
		1222217 PCGF1_HUMAN (23-127): 1.04e-30: 120: 24.07		YAF2_HUMAN (1-129): 1.37e-49: 158: 48.87
+	Hs
		718013 BMI1_HUMAN (29-324): 2e-47: 167: 12.73		RYBP_HUMAN (1-129): 3.89e-29: 108: 38.51
+	Hs
		585013 RO52_HUMAN (31-347): 2.78e-42: 157: 13.11		RYBP_HUMAN (1-129): 3.89e-29: 108: 38.51
+	Hs
		1233190 PCGF6_HUMAN (21-160): 1.24e-34: 133: 22.38		RYBP_HUMAN (1-129): 3.89e-29: 108: 38.51
+	Hs
		1108517 PCGF3_HUMAN (34-211): 2.54e-32: 124: 18.68		RYBP_HUMAN (1-129): 3.89e-29: 108: 38.51
+	Hs
		1233178 PCGF1_HUMAN (23-127): 1.04e-30: 120: 24.07		RYBP_HUMAN (1-129): 3.89e-29: 108: 38.51