HitPredict

Interactor 1: SAV (Q9VCR6)
Scaffold protein salvador (Shar-pei)
Gene: SAV

Interactor 2: KIBRA (Q9VFG8)
Protein kibra
Gene: KIBRA

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.713

Property	Details
Experiments	20159598
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	WW~WW
Common GO terms	GO:0043065 - positive regulation of apoptotic process GO:0045463 - R8 cell development GO:0045464 - R8 cell fate specification GO:0046621 - negative regulation of organ growth GO:0060090 - molecular adaptor activity and 1 others more... GO:0106037 - apicomedial cortex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 608 Dm			1 1288
+	Mm
		93257 E9PXB7_MOUSE (70-601): 1.86e-108: 347: 13.57		E9PXB7_MOUSE (32-210): 2.24e-42: 170: 23.78
+	Hs
		808278 NEDD4_HUMAN (71-601): 3.77e-90: 305: 15.59		SMUF1_HUMAN (25-238): 4.74e-56: 211: 18.60
+	Hs
		808276 NEDD4_HUMAN (71-601): 3.77e-90: 305: 15.59		SMUF2_HUMAN (4-238): 2.8e-47: 184: 16.79
+	Hs
		808041 NEDD4_HUMAN (71-601): 3.77e-90: 305: 15.59		YAP1_HUMAN (38-152): 2.99e-34: 140: 29.13
+	Hs
		808226 NEDD4_HUMAN (71-601): 3.77e-90: 305: 15.59		ITCH_HUMAN (47-162): 8.77e-30: 130: 28.21
+	Hs
		808915 WWP1_HUMAN (100-606): 4.45e-80: 273: 12.96		YAP1_HUMAN (38-152): 2.99e-34: 140: 29.13
+	Dm
		1374788 NEDD4_DROME (88-601): 7.44e-81: 276: 15.10		SUDX_DROME (40-168): 2.01e-30: 132: 28.68
+	Hs
		599553 NEDD4_HUMAN (71-601): 3.77e-90: 305: 15.59		SYT1_HUMAN (676-820): 1.15e-20: 98.3: 18.24
+	Hs
		1294856 WWP1_HUMAN (100-606): 4.45e-80: 273: 12.96		ITCH_HUMAN (47-162): 8.77e-30: 130: 28.21
+	Hs
		125703 WWP1_HUMAN (100-606): 4.45e-80: 273: 12.96		WWP2_HUMAN (34-200): 2.43e-29: 128: 23.95
+	Hs
		808040 NEDD4_HUMAN (71-601): 3.77e-90: 305: 15.59		NEDD4_HUMAN (2-217): 1.44e-15: 84.6: 17.51
+	Hs
		1334869 SMUF2_HUMAN (283-593): 7.88e-54: 197: 11.32		SMUF2_HUMAN (4-238): 2.8e-47: 184: 16.79
+	Hs
		1327908 WWP1_HUMAN (100-606): 4.45e-80: 273: 12.96		WWP1_HUMAN (9-176): 1.4e-22: 106: 23.81
+	Hs
		808235 NEDD4_HUMAN (71-601): 3.77e-90: 305: 15.59		NED4L_HUMAN (2-258): 3.97e-10: 66.5: 14.18
+	Hs
		125235 WWP2_HUMAN (253-566): 9.33e-64: 227: 15.53		YAP1_HUMAN (38-152): 2.99e-34: 140: 29.13
+	Hs
		125652 WWP2_HUMAN (253-566): 9.33e-64: 227: 15.53		ITCH_HUMAN (47-162): 8.77e-30: 130: 28.21
+	Hs
		124986 WWP2_HUMAN (253-566): 9.33e-64: 227: 15.53		WWP2_HUMAN (34-200): 2.43e-29: 128: 23.95
+	Hs
		808942 SMUF2_HUMAN (283-593): 7.88e-54: 197: 11.32		YAP1_HUMAN (38-152): 2.99e-34: 140: 29.13