HitPredict

Interactor 1: MRCK (O01583)
Serine/threonine-protein kinase mrck-1 (EC 2.7.11.1) (Myotonic dystrophy kinase-related CDC42-binding kinase homolog)
Gene: mrck-1

Interactor 2: RAN (O17915)
GTP-binding nuclear protein ran-1 (Ras-related nuclear protein 1)
Gene: ran-1

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	14704431
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	C1_1~Ras, Pkinase~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0009792 - embryo development ending in birth or egg hatching
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1592 Ce			1 215
+	Hs
		1070480 MRCKB_HUMAN (8-1568): 0: 1129: 36.55		RAB35_HUMAN (5-176): 1.19e-86: 256: 29.89
+	Hs
		1070238 MRCKA_HUMAN (8-1568): 0: 1092: 36.74		RAB35_HUMAN (5-176): 1.19e-86: 256: 29.89
+	Hs
		914124 MRCKA_HUMAN (8-1568): 0: 1092: 36.74		RB11A_HUMAN (3-204): 3.8e-78: 235: 24.76
+	Hs
		844984 MRCKA_HUMAN (8-1568): 0: 1092: 36.74		RAB7A_HUMAN (10-168): 1.56e-28: 108: 33.13
+	Hs
		647896 MARK3_HUMAN (32-757): 2.7e-153: 488: 15.12		RAB35_HUMAN (5-176): 1.19e-86: 256: 29.89
+	Hs
		1070265 MARK2_HUMAN (32-757): 5.34e-146: 469: 14.27		RAB35_HUMAN (5-176): 1.19e-86: 256: 29.89
+	Hs
		647864 MARK3_HUMAN (32-757): 2.7e-153: 488: 15.12		RB11A_HUMAN (3-204): 3.8e-78: 235: 24.76
+	Hs
		1070428 MARK1_HUMAN (25-757): 5.87e-140: 453: 13.96		RAB35_HUMAN (5-176): 1.19e-86: 256: 29.89
+	Hs
		148636 CTRO_HUMAN (2-1035): 9e-137: 470: 24.95		RAB1A_HUMAN (1-196): 9.74e-80: 238: 26.87
+	Hs
		149274 CTRO_HUMAN (2-1035): 9e-137: 470: 24.95		RAB1B_HUMAN (4-194): 1.28e-78: 235: 27.32
+	Hs
		914159 MARK2_HUMAN (32-757): 5.34e-146: 469: 14.27		RB11A_HUMAN (3-204): 3.8e-78: 235: 24.76
+	Hs
		148637 CTRO_HUMAN (2-1035): 9e-137: 470: 24.95		RAN_HUMAN (1-215): 7.12e-76: 229: 86.57
+	Hs
		682177 AKT2_HUMAN (20-416): 7.9e-129: 411: 29.95		RAB35_HUMAN (5-176): 1.19e-86: 256: 29.89
+	Hs
		148600 CTRO_HUMAN (2-1035): 9e-137: 470: 24.95		RAB10_HUMAN (10-176): 8.95e-28: 105: 32.57
+	Hs
		914081 STK38_HUMAN (67-416): 2.89e-82: 280: 40.63		RB11A_HUMAN (3-204): 3.8e-78: 235: 24.76
+	Hs
		591854 KS6A1_HUMAN (2-396): 6.81e-96: 328: 22.77		RAB4A_HUMAN (10-168): 7.42e-27: 103: 34.36
+	Hs
		270385 KS6A5_HUMAN (75-353): 6.21e-83: 293: 25.94		RAB7A_HUMAN (10-168): 1.56e-28: 108: 33.13
+	Hs
		270391 KS6A5_HUMAN (75-353): 6.21e-83: 293: 25.94		RAB10_HUMAN (10-176): 8.95e-28: 105: 32.57
+	Hs
		254466 ROCK2_HUMAN (402-1034): 3.72e-27: 123: 12.13		RB11A_HUMAN (3-204): 3.8e-78: 235: 24.76
+	Hs
		591838 ROCK1_HUMAN (368-1034): 1.26e-18: 95: 11.48		RAB4A_HUMAN (10-168): 7.42e-27: 103: 34.36