HitPredict

Interactor 1: Q9VGU4 (Q9VGU4)
FI02822p (Leash)
Gene: Leash

Interactor 2: HERC2 (Q9VR91)
Probable E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)
Gene: HERC2

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	38270169
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 520 Dm			1 4912
+	Hs
		320008 TXNIP_HUMAN (3-409): 4.2e-89: 280: 17.12		HERC2_HUMAN (79-4894): 0: 5422: 42.13
+	Dm
		1366476 Q9VGU4_DROME (1-520): 1.72e-116: 355: 100.00		SUDX_DROME (4412-4882): 1.12e-155: 513: 20.24
+	Dm
		115612 Q9VGU4_DROME (1-520): 1.72e-116: 355: 100.00		M9PFK2_DROME (4406-4879): 7.55e-155: 512: 21.74
+	Dm
		1366431 Q9VGU4_DROME (1-520): 1.72e-116: 355: 100.00		NEDD4_DROME (4406-4879): 7.96e-155: 512: 21.74
+	Dm
		1366460 Q9VGU4_DROME (1-520): 1.72e-116: 355: 100.00		Q9W325_DROME (4455-4882): 3.55e-148: 471: 20.67
+	Dm
		115611 Q8SYU5_DROME (3-475): 2.07e-100: 312: 23.41		M9PFK2_DROME (4406-4879): 7.55e-155: 512: 21.74
+	Dm
		1249345 Q8SYU5_DROME (3-475): 2.07e-100: 312: 23.41		NEDD4_DROME (4406-4879): 7.96e-155: 512: 21.74
+	Dm
		89902 Q9VGU4_DROME (1-520): 1.72e-116: 355: 100.00		D5SHR3_DROME (4473-4882): 9.98e-147: 466: 20.84
+	Dm
		1367634 Q9VI00_DROME (1-442): 6.46e-97: 302: 15.44		SUDX_DROME (4412-4882): 1.12e-155: 513: 20.24
+	Dm
		115614 Q9VI00_DROME (1-442): 6.46e-97: 302: 15.44		M9PFK2_DROME (4406-4879): 7.55e-155: 512: 21.74
+	Dm
		1367624 Q9VI00_DROME (1-442): 6.46e-97: 302: 15.44		NEDD4_DROME (4406-4879): 7.96e-155: 512: 21.74
+	Ce
		1341514 Q9XXI4_CAEEL (5-400): 2.85e-98: 305: 18.18		WWP1_CAEEL (4408-4882): 3e-154: 503: 19.21
+	Hs
		125707 TXNIP_HUMAN (3-409): 4.2e-89: 280: 17.12		WWP2_HUMAN (4414-4882): 1.29e-160: 524: 20.95
+	Dm
		1249359 Q8SYU5_DROME (3-475): 2.07e-100: 312: 23.41		Q9W325_DROME (4455-4882): 3.55e-148: 471: 20.67
+	Dm
		89895 Q8SYU5_DROME (3-475): 2.07e-100: 312: 23.41		D5SHR3_DROME (4473-4882): 9.98e-147: 466: 20.84
+	Dm
		1367630 Q9VI00_DROME (1-442): 6.46e-97: 302: 15.44		Q9W325_DROME (4455-4882): 3.55e-148: 471: 20.67
+	Dm
		89904 Q9VI00_DROME (1-442): 6.46e-97: 302: 15.44		D5SHR3_DROME (4473-4882): 9.98e-147: 466: 20.84
+	Dm
		1337204 Q9I7L0_DROME (5-436): 3.17e-93: 292: 23.57		Q9W325_DROME (4455-4882): 3.55e-148: 471: 20.67
+	Hs
		1192211 TXNIP_HUMAN (3-409): 4.2e-89: 280: 17.12		HUWE1_HUMAN (4413-4881): 3.44e-135: 482: 21.16
+	Dm
		89897 Q9I7L0_DROME (5-436): 3.17e-93: 292: 23.57		D5SHR3_DROME (4473-4882): 9.98e-147: 466: 20.84