HitPredict

Interactor 1: O01964 (O01964)
RBR-type E3 ubiquitin transferase (EC 2.3.2.31)
Gene: ari-1.2

Interactor 2: UBC18 (Q21633)
Ubiquitin-conjugating enzyme E2 ubc-18 (EC 2.3.2.23)
Gene: ubc-18

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.40	1.00	0.637

Property	Details
Experiments	19123269
Identification Methods	two hybrid array, two hybrid pooling approach
Interaction Type	physical association

Property	Details
Interacting Pfam domains	IBR~UQ_con
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0000209 - protein polyubiquitination GO:0005634 - nucleus GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 497 Ce			1 153
+	Ce
		137091 ARI11_CAEEL (1-497): 0: 585: 75.25		UBC18_CAEEL (1-153): 4.41e-72: 214: 100.00
+	Ce
		137086 O01963_CAEEL (1-497): 0: 554: 73.64		UBC18_CAEEL (1-153): 4.41e-72: 214: 100.00
+	Hs
		849498 ARI1_HUMAN (46-497): 0: 523: 48.60		UB2D1_HUMAN (2-149): 4.65e-75: 222: 36.91
+	Ce
		1094319 Q9NA31_CAEEL (1-497): 0: 526: 54.94		UBC18_CAEEL (1-153): 4.41e-72: 214: 100.00
+	Hs
		895968 ARI1_HUMAN (46-497): 0: 523: 48.60		UB2D3_HUMAN (2-149): 2.57e-73: 217: 35.57
+	Hs
		1297383 ARI1_HUMAN (46-497): 0: 523: 48.60		UB2E2_HUMAN (2-148): 3.43e-69: 209: 31.08
+	Dm
		1180448 ARI1_DROME (1-497): 1.16e-180: 517: 45.37		UBC10_DROME (1-152): 1.27e-68: 206: 59.87
+	Hs
		932603 ARI1_HUMAN (46-497): 0: 523: 48.60		UB2L3_HUMAN (1-152): 1.96e-66: 200: 59.21
+	Mm
		932612 ARI1_MOUSE (46-497): 0: 523: 48.60		UB2L3_MOUSE (1-152): 1.96e-66: 200: 59.21
+	Dm
		1180449 Q9VT94_DROME (1-497): 1.07e-178: 513: 44.29		UBC10_DROME (1-152): 1.27e-68: 206: 59.87
+	Hs
		896576 ARI1_HUMAN (46-497): 0: 523: 48.60		UBE2N_HUMAN (4-148): 1.23e-64: 195: 35.62
+	Ce
		88104 D3NQB4_CAEEL (65-497): 8.08e-173: 495: 59.73		UBC18_CAEEL (1-153): 4.41e-72: 214: 100.00
+	Hs
		312520 ARI2_HUMAN (1-486): 8.29e-155: 451: 29.70		UB2D1_HUMAN (2-149): 4.65e-75: 222: 36.91
+	Hs
		312528 ARI2_HUMAN (1-486): 8.29e-155: 451: 29.70		UB2D3_HUMAN (2-149): 2.57e-73: 217: 35.57
+	Hs
		159108 ARI1_HUMAN (46-497): 0: 523: 48.60		UB2L6_HUMAN (1-152): 2.02e-42: 139: 47.37
+	Dm
		284374 ARI2_DROME (1-484): 5.12e-156: 455: 29.67		UBC10_DROME (1-152): 1.27e-68: 206: 59.87
+	Hs
		312522 ARI2_HUMAN (1-486): 8.29e-155: 451: 29.70		UB2E1_HUMAN (2-148): 1.6e-67: 204: 31.08
+	Hs
		312529 ARI2_HUMAN (1-486): 8.29e-155: 451: 29.70		UBE2N_HUMAN (4-148): 1.23e-64: 195: 35.62
+	Dm
		284368 ARI2_DROME (1-484): 5.12e-156: 455: 29.67		UBC84_DROME (1-153): 1.3e-61: 188: 60.13
+	Hs
		159008 ARI2_HUMAN (1-486): 8.29e-155: 451: 29.70		UB2L6_HUMAN (1-152): 2.02e-42: 139: 47.37