HitPredict

Interactor 1: ARI11 (O01965)
E3 ubiquitin-protein ligase ari-1.1 (EC 2.3.2.31)
Gene: ari-1.1

Interactor 2: UBC18 (Q21633)
Ubiquitin-conjugating enzyme E2 ubc-18 (EC 2.3.2.23)
Gene: ubc-18

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.830

Property	Details
Experiments	16457801, 19123269
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	IBR~UQ_con
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0000209 - protein polyubiquitination GO:0005634 - nucleus GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 494 Ce			1 153
+	Ce
		137089 O01964_CAEEL (1-494): 0: 556: 75.05		UBC18_CAEEL (1-153): 4.41e-72: 214: 100.00
+	Ce
		137086 O01963_CAEEL (1-494): 0: 552: 75.91		UBC18_CAEEL (1-153): 4.41e-72: 214: 100.00
+	Hs
		849498 ARI1_HUMAN (43-494): 3.67e-177: 510: 53.78		UB2D1_HUMAN (2-149): 4.65e-75: 222: 36.91
+	Ce
		1094319 Q9NA31_CAEEL (1-494): 6.56e-180: 515: 58.85		UBC18_CAEEL (1-153): 4.41e-72: 214: 100.00
+	Hs
		895968 ARI1_HUMAN (43-494): 3.67e-177: 510: 53.78		UB2D3_HUMAN (2-149): 2.57e-73: 217: 35.57
+	Dm
		1180448 ARI1_DROME (1-494): 0: 520: 50.20		UBC10_DROME (1-152): 1.27e-68: 206: 59.87
+	Hs
		1297383 ARI1_HUMAN (43-494): 3.67e-177: 510: 53.78		UB2E2_HUMAN (2-148): 3.43e-69: 209: 31.08
+	Hs
		932603 ARI1_HUMAN (43-494): 3.67e-177: 510: 53.78		UB2L3_HUMAN (1-152): 1.96e-66: 200: 59.21
+	Mm
		932612 ARI1_MOUSE (43-494): 4.46e-177: 510: 53.78		UB2L3_MOUSE (1-152): 1.96e-66: 200: 59.21
+	Hs
		896576 ARI1_HUMAN (43-494): 3.67e-177: 510: 53.78		UBE2N_HUMAN (4-148): 1.23e-64: 195: 35.62
+	Dm
		1180449 Q9VT94_DROME (1-494): 3.92e-173: 498: 46.23		UBC10_DROME (1-152): 1.27e-68: 206: 59.87
+	Ce
		88104 D3NQB4_CAEEL (62-494): 1.61e-168: 484: 63.12		UBC18_CAEEL (1-153): 4.41e-72: 214: 100.00
+	Hs
		312520 ARI2_HUMAN (4-483): 1.21e-148: 435: 30.92		UB2D1_HUMAN (2-149): 4.65e-75: 222: 36.91
+	Hs
		312528 ARI2_HUMAN (4-483): 1.21e-148: 435: 30.92		UB2D3_HUMAN (2-149): 2.57e-73: 217: 35.57
+	Dm
		284374 ARI2_DROME (1-482): 7.01e-152: 444: 29.40		UBC10_DROME (1-152): 1.27e-68: 206: 59.87
+	Hs
		159108 ARI1_HUMAN (43-494): 3.67e-177: 510: 53.78		UB2L6_HUMAN (1-152): 2.02e-42: 139: 47.37
+	Hs
		312522 ARI2_HUMAN (4-483): 1.21e-148: 435: 30.92		UB2E1_HUMAN (2-148): 1.6e-67: 204: 31.08
+	Dm
		284368 ARI2_DROME (1-482): 7.01e-152: 444: 29.40		UBC84_DROME (1-153): 1.3e-61: 188: 60.13
+	Hs
		312529 ARI2_HUMAN (4-483): 1.21e-148: 435: 30.92		UBE2N_HUMAN (4-148): 1.23e-64: 195: 35.62
+	Hs
		159008 ARI2_HUMAN (4-483): 1.21e-148: 435: 30.92		UB2L6_HUMAN (1-152): 2.02e-42: 139: 47.37