HitPredict

Interactor 1: PSF2 (Q9VQY9)
Probable DNA replication complex GINS protein PSF2 (GINS complex subunit 2)
Gene: PSF2

Interactor 2: MCM3 (Q9XYU1)
DNA replication licensing factor Mcm3 (EC 3.6.4.12) (Minichromosome maintenance 3 protein) (DmMCM3)
Gene: MCM3

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	16798881, 21378962, 25117490
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	MCM~Sld5, MCM_N~Sld5
Common GO terms	GO:0000727 - double-strand break repair via break-induced replication GO:0005634 - nucleus GO:0006271 - DNA strand elongation involved in DNA replication GO:0071162 - CMG complex
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 203 Dm			1 819
+	Hs
		709116 PSF2_HUMAN (1-182): 1.3e-93: 272: 42.31		MCM7_HUMAN (5-665): 0: 688: 32.79
+	Dm
		832231 PSF2_DROME (1-203): 1.26e-90: 265: 100.00		MCM2_DROME (11-722): 0: 686: 30.19
+	Dm
		1366523 PSF2_DROME (1-203): 1.26e-90: 265: 100.00		MCM5_DROME (7-727): 0: 666: 29.70
+	Dm
		1359685 PSF2_DROME (1-203): 1.26e-90: 265: 100.00		MCM6_DROME (2-783): 0: 662: 23.89
+	Dm
		1099477 PSF2_DROME (1-203): 1.26e-90: 265: 100.00		MCM4_DROME (6-738): 0: 651: 26.21
+	Sc
		622167 PSF2_YEAST (3-173): 1.15e-48: 159: 27.37		MCM3_YEAST (42-819): 0: 691: 41.22
+	Sc
		667592 PSF2_YEAST (3-173): 1.15e-48: 159: 27.37		MCM2_YEAST (8-650): 0: 663: 31.76
+	Dm
		1372791 PSF2_DROME (1-203): 1.26e-90: 265: 100.00		MCM7_DROME (97-646): 1.59e-86: 291: 37.43
+	Sc
		667859 PSF2_YEAST (3-173): 1.15e-48: 159: 27.37		MCM5_YEAST (111-644): 7.01e-91: 305: 35.36
+	Sc
		744775 PSF2_YEAST (3-173): 1.15e-48: 159: 27.37		MCM7_YEAST (105-646): 4.01e-86: 293: 36.87