HitPredict

Interactor 1: CPSF6 (Q9VSH4)
Cleavage and polyadenylation specificity factor subunit 6
Gene: CPSF6

Interactor 2: Q9VSY2 (Q9VSY2)
Cleavage and polyadenylation specificity factor subunit 5
Gene: Cpsf5

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.775

Property	Details
Experiments	14605208, 22036573
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	NUDIX_2~RRM_1
Common GO terms	GO:0003729 - mRNA binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 652 Dm			1 203
+	Mm
		1156797 CPSF6_MOUSE (1-556): 6.61e-33: 135: 35.54		CPSF5_MOUSE (8-192): 2.6e-112: 321: 74.33
+	Hs
		214944 CPSF6_HUMAN (1-556): 4.6e-33: 136: 35.89		CPSF5_HUMAN (8-192): 1.89e-111: 319: 73.80
+	Hs
		214990 CPSF7_HUMAN (5-560): 2.66e-32: 132: 29.89		CPSF5_HUMAN (8-192): 1.89e-111: 319: 73.80
+	Ce
		1090396 Q18937_CAEEL (3-519): 5.63e-45: 169: 30.00		Q93716_CAEEL (43-194): 2.15e-91: 268: 70.40
+	Ce
		86387 C1P629_CAEEL (3-519): 6.99e-43: 163: 29.89		Q93716_CAEEL (43-194): 2.15e-91: 268: 70.40