HitPredict

Interactor 1: Q9VTQ9 (Q9VTQ9)
AT06668p (Regulatory particle triple-A ATPase 4-related, isoform A) (Regulatory particle triple-A ATPase 4-related, isoform B (EC 5.6.1.5))
Gene: Rpt4R

Interactor 2: Q9VW54 (Q9VW54)
26S proteasome non-ATPase regulatory subunit 2
Gene: Rpn1

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	19079254
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA_lid_3~RPN1_C, AAA_lid_3~RPN1_RPN2_N
Common GO terms	GO:0008540 - proteasome regulatory particle, base subcomplex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 398 Dm			1 919
+	Hs
		1027680 Q53HB3_HUMAN (4-389): 3.49e-159: 456: 41.71		PSMD2_HUMAN (3-917): 0: 1154: 60.89
+	Hs
		1027683 Q53XL8_HUMAN (4-389): 1.17e-136: 399: 41.71		PSMD2_HUMAN (3-917): 0: 1154: 60.89
+	Hs
		906819 PRS4_HUMAN (4-389): 1.17e-136: 399: 41.71		PSMD2_HUMAN (3-917): 0: 1154: 60.89
+	Hs
		66339 A8K2M0_HUMAN (9-390): 1.54e-131: 385: 41.10		PSMD2_HUMAN (3-917): 0: 1154: 60.89
+	Hs
		798648 PRS6B_HUMAN (9-390): 1.54e-131: 385: 41.10		PSMD2_HUMAN (3-917): 0: 1154: 60.89
+	Dm
		820527 PRS4_DROME (1-389): 2.65e-158: 454: 41.13		Q9VW54_DROME (1-919): 0: 1058: 100.00
+	Dm
		1359419 Q9V405_DROME (8-390): 1.12e-131: 385: 40.99		Q9VW54_DROME (1-919): 0: 1058: 100.00
+	At
		1352075 PRS6B_ARATH (11-396): 2.97e-137: 399: 40.93		PSD2A_ARATH (43-919): 0: 1005: 47.98
+	At
		1277634 PRS8B_ARATH (13-393): 1.16e-131: 385: 45.55		PSD2A_ARATH (43-919): 0: 1005: 47.98
+	At
		1352343 PRS7A_ARATH (78-383): 5.07e-105: 318: 49.02		PSD2A_ARATH (43-919): 0: 1005: 47.98
+	Sc
		753922 PRS8_YEAST (22-393): 5.42e-104: 315: 45.16		RPN1_YEAST (47-919): 0: 879: 39.67
+	Sc
		703894 PRS7_YEAST (78-395): 1.97e-102: 313: 47.96		RPN1_YEAST (47-919): 0: 879: 39.67
+	Hs
		906907 PRS4_HUMAN (4-389): 1.17e-136: 399: 41.71		PSMD1_HUMAN (57-856): 0: 764: 17.41
+	Hs
		798739 PRS6B_HUMAN (9-390): 1.54e-131: 385: 41.10		PSMD1_HUMAN (57-856): 0: 764: 17.41
+	Dm
		820502 PRS4_DROME (1-389): 2.65e-158: 454: 41.13		PSMD1_DROME (57-856): 0: 664: 17.40
+	Hs
		693 PRS6B_HUMAN (9-390): 1.54e-131: 385: 41.10		A0A087WW66_HUMAN (57-856): 0: 697: 17.01
+	Dm
		1359001 Q9V405_DROME (8-390): 1.12e-131: 385: 40.99		PSMD1_DROME (57-856): 0: 664: 17.40
+	Dm
		1181026 Q7KMQ0_DROME (78-383): 1.31e-102: 312: 48.37		PSMD1_DROME (57-856): 0: 664: 17.40
+	Sc
		693349 PRS8_YEAST (22-393): 5.42e-104: 315: 45.16		RPN2_YEAST (57-863): 0: 617: 17.52
+	Sc
		693271 PRS7_YEAST (78-395): 1.97e-102: 313: 47.96		RPN2_YEAST (57-863): 0: 617: 17.52