HitPredict

Interactor 1: AGO2 (Q9VUQ5)
Protein argonaute-2
Gene: AGO2

Interactor 2: SND1 (Q9W0S7)
Staphylococcal nuclease domain-containing protein 1 (EC 3.1.31.1) (Tudor staphylococcal nuclease)
Gene: Tudor-SN

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	14508492, 25294943
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016442 - RISC complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1214 Dm			1 926
+	Rn
		1146473 AGO2_RAT (392-1213): 0: 957: 29.01		SND1_RAT (26-925): 0: 1018: 50.27
+	Ce
		108514 G5EGR6_CAEEL (266-1213): 0: 880: 25.94		Q19328_CAEEL (2-921): 0: 953: 46.52
+	Hs
		1183008 PIWL1_HUMAN (332-1199): 0: 732: 19.78		SND1_HUMAN (18-925): 0: 1024: 50.16
+	Mm
		1176477 PIWL1_MOUSE (325-1199): 0: 723: 19.69		SND1_MOUSE (26-925): 0: 1018: 50.16
+	Hs
		1294950 PIWL1_HUMAN (332-1199): 0: 732: 19.78		TDRKH_HUMAN (534-898): 9.71e-78: 265: 19.16
+	Mm
		1194349 PIWL1_MOUSE (325-1199): 0: 723: 19.69		TDRKH_MOUSE (534-898): 1.18e-77: 265: 19.63
+	Hs
		1189716 PIWL4_HUMAN (401-1199): 0: 619: 19.78		TDRKH_HUMAN (534-898): 9.71e-78: 265: 19.16
+	Dr
		57792 PIWL2_DANRE (129-1203): 0: 654: 17.70		TDRD9_DANRE (644-905): 7.3e-49: 190: 17.46
+	Dm
		1186012 AGO3_DROME (408-1199): 0: 625: 20.12		TDRKH_DROME (545-888): 1.1e-52: 196: 15.53
+	Dr
		1123241 PIWL1_DANRE (326-1198): 0: 697: 19.15		TDRD1_DANRE (660-900): 1.25e-27: 123: 18.75
+	Dr
		57794 PIWL2_DANRE (129-1203): 0: 654: 17.70		F1QTF8_DANRE (677-871): 7.23e-39: 158: 16.75
+	Dr
		57797 PIWL2_DANRE (129-1203): 0: 654: 17.70		TDRD5_DANRE (654-884): 5.92e-39: 158: 19.03
+	Dm
		1369531 PIWI_DROME (337-1199): 0: 608: 19.05		TDRKH_DROME (545-888): 1.1e-52: 196: 15.53
+	Mm
		1208145 PIWL2_MOUSE (215-1198): 0: 675: 18.02		TDRD1_MOUSE (663-905): 3.08e-28: 124: 21.03
+	Dm
		1000947 AGO3_DROME (408-1199): 0: 625: 20.12		Q0E910_DROME (513-882): 1.37e-38: 158: 16.17
+	Dr
		57799 PIWL2_DANRE (129-1203): 0: 654: 17.70		TDRD1_DANRE (660-900): 1.25e-27: 123: 18.75
+	Dm
		55036 AGO3_DROME (408-1199): 0: 625: 20.12		A1ZAC4_DROME (552-884): 5.75e-34: 141: 14.03
+	Dr
		57795 PIWL2_DANRE (129-1203): 0: 654: 17.70		F1R3C5_DANRE (694-881): 2.47e-13: 76.4: 15.35
+	Dm
		639169 AGO3_DROME (408-1199): 0: 625: 20.12		TUD_DROME (701-910): 2.21e-17: 89.9: 15.63
+	Dm
		1364334 PIWI_DROME (337-1199): 0: 608: 19.05		Q9VE55_DROME (448-906): 7.85e-18: 91.4: 13.13