HitPredict

Interactor 1: Q9VVJ5 (Q9VVJ5)
Nedd4 family interacting protein (SD09769p)
Gene: Ndfip

Interactor 2: SUDX (Q9Y0H4)
E3 ubiquitin-protein ligase Su(dx) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase Su(dx)) (Protein suppressor of deltex)
Gene: Su(dx)

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	20966964, 30213861
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0045746 - negative regulation of Notch signaling pathway
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 267 Dm			1 949
+	Dm
		1374786 Q9VVJ5_DROME (1-267): 3.24e-164: 457: 100.00		NEDD4_DROME (12-947): 0: 767: 29.18
+	Hs
		1294848 NFIP1_HUMAN (150-267): 3.85e-57: 184: 41.32		ITCH_HUMAN (34-949): 0: 882: 49.02
+	Hs
		1294871 NFIP2_HUMAN (53-266): 4.38e-54: 179: 30.05		ITCH_HUMAN (34-949): 0: 882: 49.02
+	Mm
		1208047 NFIP1_MOUSE (150-267): 2.34e-57: 184: 42.15		ITCH_MOUSE (34-949): 0: 866: 48.21
+	Hs
		1311857 NFIP1_HUMAN (150-267): 3.85e-57: 184: 41.32		WWP1_HUMAN (27-949): 0: 858: 51.42
+	Hs
		1327920 NFIP2_HUMAN (53-266): 4.38e-54: 179: 30.05		WWP1_HUMAN (27-949): 0: 858: 51.42
+	Hs
		125686 NFIP1_HUMAN (150-267): 3.85e-57: 184: 41.32		WWP2_HUMAN (34-949): 0: 844: 52.01
+	Hs
		125746 NFIP2_HUMAN (53-266): 4.38e-54: 179: 30.05		WWP2_HUMAN (34-949): 0: 844: 52.01
+	Hs
		1299617 NFIP1_HUMAN (150-267): 3.85e-57: 184: 41.32		NED4L_HUMAN (45-946): 0: 812: 32.00
+	Hs
		1299647 NFIP2_HUMAN (53-266): 4.38e-54: 179: 30.05		NED4L_HUMAN (45-946): 0: 812: 32.00
+	Mm
		93279 NFIP1_MOUSE (150-267): 2.34e-57: 184: 42.15		E9PXB7_MOUSE (143-946): 0: 717: 33.06
+	Hs
		808249 NFIP1_HUMAN (150-267): 3.85e-57: 184: 41.32		NEDD4_HUMAN (120-946): 0: 712: 33.81
+	Hs
		808291 NFIP2_HUMAN (53-266): 4.38e-54: 179: 30.05		NEDD4_HUMAN (120-946): 0: 712: 33.81
+	Dm
		1360300 Q9VVJ5_DROME (1-267): 3.24e-164: 457: 100.00		SMUF1_DROME (42-560): 2.72e-42: 169: 14.26
+	Rn
		1137274 NFIP1_RAT (150-267): 2.66e-57: 184: 41.32		NEDD4_RAT (1-446): 1.17e-56: 213: 19.10
+	Mm
		808368 NFIP1_MOUSE (150-267): 2.34e-57: 184: 42.15		NEDD4_MOUSE (45-446): 4.51e-54: 205: 19.64
+	Hs
		1311860 NFIP1_HUMAN (150-267): 3.85e-57: 184: 41.32		SMUF1_HUMAN (37-459): 6.6e-42: 166: 15.31