HitPredict

Interactor 1: NFKB1 (Q94527)
Nuclear factor NF-kappa-B p110 subunit (Rel-p110) (Relish protein) [Cleaved into: Nuclear factor NF-kappa-B p68 subunit (Rel-p68); Nuclear factor NF-kappa-B p49 subunit (Rel-p49)]
Gene: Rel

Interactor 2: NEMO (Q9GYV5)
NF-kappa-B essential modulator (Inhibitor of nuclear factor kappa B kinase subunit gamma) (DmIKKgamma) (NEMO homolog)
Gene: key

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.90	0.775

The method score is based on:

Property	Details
Experiments	25242320, 22036573, 38944040
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Ank_2~CC2-LZ
Common GO terms	GO:0002230 - positive regulation of defense response to virus by host GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006955 - immune response and 7 others more... GO:0006963 - positive regulation of antibacterial peptide biosynthetic process GO:0045089 - positive regulation of innate immune response GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0050829 - defense response to Gram-negative bacterium GO:0051607 - defense response to virus GO:0061057 - peptidoglycan recognition protein signaling pathway GO:2000647 - negative regulation of stem cell proliferation
Homologous interactions	0

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Last updated: 11Aug2025