HitPredict

Interactor 1: Q9W102 (Q9W102)
Origin recognition complex subunit 4
Gene: Orc4

Interactor 2: ORC6 (Q9Y1B2)
Origin recognition complex subunit 6
Gene: ORC6

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.720

Property	Details
Experiments	24137536, 27016737, 25762138, 29899147, 32848132
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005664 - nuclear origin of replication recognition complex GO:0006270 - DNA replication initiation
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 459 Dm			1 257
+	Hs
		217846 ORC4_HUMAN (8-458): 1.58e-131: 388: 42.20		ORC6_HUMAN (2-241): 3.24e-98: 288: 27.82
+	Dm
		184173 ORC1_DROME (1-375): 8.19e-96: 310: 15.58		ORC6_DROME (1-257): 5.75e-113: 326: 100.00
+	At
		1150972 ORC4_ARATH (3-448): 1.25e-108: 329: 26.89		ORC6_ARATH (5-233): 3.57e-92: 275: 22.58
+	Hs
		1306132 CDC6_HUMAN (12-372): 2.7e-95: 299: 14.73		ORC6_HUMAN (2-241): 3.24e-98: 288: 27.82
+	At
		1352830 ORC1B_ARATH (4-447): 5.83e-94: 302: 13.53		ORC6_ARATH (5-233): 3.57e-92: 275: 22.58
+	Dm
		1373671 Q9VSM9_DROME (6-377): 1.06e-73: 246: 13.76		ORC6_DROME (1-257): 5.75e-113: 326: 100.00