HitPredict

Interactor 1: CUL1 (Q9WTX6)
Cullin-1 (CUL-1)
Gene: CUL1

Interactor 2: SKP2 (Q9Z0Z3)
S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/WD-40 protein 1) (FWD1)
Gene: SKP2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.76 1.00 0.873

The method score is based on:

Property Details
Experiments 12417738, 11735228, 23868976, 24390425
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Cullin~F-box-like
Common GO terms GO:0005654 - nucleoplasm
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0019005 - SCF ubiquitin ligase complex
GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0070936 - protein K48-linked ubiquitination
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 776
Mm

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024