HitPredict

Interactor 1: TBK1 (Q9WUN2)
Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (T2K) (TANK-binding kinase 1)
Gene: TBK1

Interactor 2: TBK1 (Q9WUN2)
Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (T2K) (TANK-binding kinase 1)
Gene: TBK1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.69 1.00 0.834

The method score is based on:

Property Details
Experiments 23746807, 22728658
Identification Methods x-ray crystallography, protein kinase assay, molecular sieving
Interaction Type association, phosphorylation reaction, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase, Pkinase~TBK1_CCD1, Pkinase~TBK1_ULD, TBK1_CCD1~TBK1_CCD1, TBK1_CCD1~TBK1_ULD, TBK1_ULD~TBK1_ULD
Common GO terms GO:0002218 - activation of innate immune response
GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway
GO:0003676 - nucleic acid binding
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
and 25 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 729
Mm

1 729
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+ Gm
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Last updated: 15 Jul 2024