HitPredict

Interactor 1: Q9WYT9 (Q9WYT9)
Response regulator
Gene: TM_0468

Interactor 2: Q9WZV7 (Q9WZV7)
histidine kinase (EC 2.7.13.3)
Gene: TM_0853

Species: Thermotoga maritima MSB8

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.849

Property	Details
Experiments	23954504, 19800110
Identification Methods	phosphotransferase assay, x-ray crystallography, comigration in non denaturing gel electrophoresis
Interaction Type	direct interaction, phosphotransfer reaction

Property	Details
Interacting Pfam domains	HATPase_c~Response_reg, HisKA~Response_reg
Common GO terms	GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 122 Tm			1 489
+	Mx
		1091444 Q1D1K9_MYXXD (1-121): 2.66e-45: 148: 38.84		Q1D333_MYXXD (95-483): 2.1e-76: 248: 27.41
+	Ss
		937372 P72843_SYNY3 (3-120): 2.81e-41: 146: 36.44		P73932_SYNY3 (156-488): 5.07e-73: 250: 24.85
+	Ss
		938972 P74014_SYNY3 (3-117): 4.42e-41: 141: 28.70		P74015_SYNY3 (72-479): 2.46e-77: 255: 22.41
+	Mx
		1091476 Q1D948_MYXXD (2-121): 6.24e-41: 145: 33.33		Q1D333_MYXXD (95-483): 2.1e-76: 248: 27.41
+	Mx
		1091479 Q1DCL7_MYXXD (5-121): 3.33e-43: 142: 39.32		Q1D333_MYXXD (95-483): 2.1e-76: 248: 27.41
+	Ss
		937371 P72843_SYNY3 (3-120): 2.81e-41: 146: 36.44		P73828_SYNY3 (162-476): 5.23e-70: 242: 24.86
+	Bt
		1206284 Q89YR8_BACTN (4-121): 3.04e-42: 149: 35.59		Q89YR8_BACTN (237-479): 5.18e-68: 238: 33.33
+	Mx
		1091552 Q1D948_MYXXD (2-121): 6.24e-41: 145: 33.33		Q1D8M1_MYXXD (176-481): 1.94e-69: 241: 26.24
+	Ss
		937876 P73104_SYNY3 (2-122): 8.88e-46: 148: 38.02		Q55783_SYNY3 (255-486): 7.41e-73: 238: 28.02
+	Mx
		1091248 Q1D1K9_MYXXD (1-121): 2.66e-45: 148: 38.84		Q1CVV2_MYXXD (180-476): 4.27e-68: 235: 32.45
+	Mx
		1091500 Q1D4T4_MYXXD (3-121): 4.71e-43: 142: 41.18		Q1D8M1_MYXXD (176-481): 1.94e-69: 241: 26.24
+	Mx
		1091251 Q1D948_MYXXD (2-121): 6.24e-41: 145: 33.33		Q1CVV2_MYXXD (180-476): 4.27e-68: 235: 32.45
+	Ec
		439475 PHOB_ECOLI (1-121): 6.74e-49: 157: 38.02		PHOR_ECOLI (111-485): 2.95e-67: 223: 24.35
+	Ss
		937545 P72948_SYNY3 (3-121): 6.37e-45: 147: 34.45		Q55475_SYNY3 (239-477): 9.44e-70: 229: 29.63
+	Cv
		1308005 Q9ABD5_CAUVC (1-121): 4.11e-47: 152: 38.02		Q9ABD9_CAUVC (149-480): 7.9e-66: 221: 22.69
+	Mx
		1091564 Q1D948_MYXXD (2-121): 6.24e-41: 145: 33.33		Q1DCL6_MYXXD (168-481): 8.36e-67: 225: 32.17
+	Mx
		1091414 Q1D1K9_MYXXD (1-121): 2.66e-45: 148: 38.84		Q1D0A1_MYXXD (217-477): 3.36e-23: 104: 28.79
+	Mx
		1091555 Q1D948_MYXXD (2-121): 6.24e-41: 145: 33.33		Q1D8M7_MYXXD (242-472): 1.63e-23: 105: 29.87
+	Ss
		937709 P73104_SYNY3 (2-122): 8.88e-46: 148: 38.02		P73025_SYNY3 (236-478): 1.61e-22: 102: 27.57
+	Mx
		1091421 Q1D948_MYXXD (2-121): 6.24e-41: 145: 33.33		Q1D0A1_MYXXD (217-477): 3.36e-23: 104: 28.79