HitPredict - High confidence protein-protein interactions

Interactor 1: RUVB2 (Q9Y230)
RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta)
Gene: RUVBL2

Interactor 2: RUVB1 (Q9Y265)
RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
Gene: RUVBL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.98	1.00	0.993

Property	Details
Experiments	25416956, 25636407, 28514442, 28561026, 17353931, 25437307, 29892012, 32296183, 33961781, 35271311, 35235311, 17643375, 19433865, 18087039, 17636026, 17721549, 10966108, 18358808, 11080158, 10524211 and 9 others more... 20371770, 26264872, 37071682, 17157868, 20603076, 29323271, 20211142, 16230350, unassigned1304
Identification Methods	two hybrid, pull down, affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, 3D electron microscopy, two hybrid array, two hybrid prey pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	TIP49~TIP49, TIP49~TIP49_C
Common GO terms	GO:0000723 - telomere maintenance GO:0000492 - box C/D snoRNP assembly GO:0000786 - nucleosome GO:0000812 - Swr1 complex GO:0001094 - TFIID-class transcription factor complex binding and 40 others more... GO:0003678 - DNA helicase activity GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005813 - centrosome GO:0005829 - cytosol GO:0006275 - regulation of DNA replication GO:0006281 - DNA repair GO:0006282 - regulation of DNA repair GO:0006310 - DNA recombination GO:0006338 - chromatin remodeling GO:0006355 - regulation of DNA-templated transcription GO:0006357 - regulation of transcription by RNA polymerase II GO:0016020 - membrane GO:0016363 - nuclear matrix GO:0016887 - ATP hydrolysis activity GO:0017025 - TBP-class protein binding GO:0031011 - Ino80 complex GO:0033044 - regulation of chromosome organization GO:0035267 - NuA4 histone acetyltransferase complex GO:0042981 - regulation of apoptotic process GO:0043531 - ADP binding GO:0045739 - positive regulation of DNA repair GO:0045893 - positive regulation of DNA-templated transcription GO:0045995 - regulation of embryonic development GO:0050821 - protein stabilization GO:0051117 - ATPase binding GO:0051726 - regulation of cell cycle GO:0060382 - regulation of DNA strand elongation GO:0070062 - extracellular exosome GO:0071339 - MLL1 complex GO:0097255 - R2TP complex GO:0101031 - protein folding chaperone complex GO:0120293 - dynein axonemal particle GO:1904507 - positive regulation of telomere maintenance in response to DNA damage GO:1904874 - positive regulation of telomerase RNA localization to Cajal body GO:1905168 - positive regulation of double-strand break repair via homologous recombination GO:1990062 - RPAP3/R2TP/prefoldin-like complex GO:1990904 - ribonucleoprotein complex GO:2000779 - regulation of double-strand break repair
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1	463
Hs

1	456

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024