HitPredict

Interactor 1: RUVB1 (Q9Y265)
RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
Gene: RUVBL1

Interactor 2: UCHL5 (Q9Y5K5)
Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5)
Gene: UCHL5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.722

The method score is based on:

Property	Details
Experiments	33961781, 35271311, 17721549, 28514442, 18922472
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000723 - telomere maintenance GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006275 - regulation of DNA replication and 12 others more... GO:0006281 - DNA repair GO:0006282 - regulation of DNA repair GO:0006310 - DNA recombination GO:0006338 - chromatin remodeling GO:0031011 - Ino80 complex GO:0033044 - regulation of chromosome organization GO:0045739 - positive regulation of DNA repair GO:0045893 - positive regulation of DNA-templated transcription GO:0045995 - regulation of embryonic development GO:0051726 - regulation of cell cycle GO:0060382 - regulation of DNA strand elongation GO:1904507 - positive regulation of telomere maintenance in response to DNA damage
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	456
Hs

1	329

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024