HitPredict - High confidence protein-protein interactions

Interactor 1: CARD8 (Q9Y2G2)
Caspase recruitment domain-containing protein 8 (EC 3.4.-.-) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor up-regulated CARD-containing antagonist of CASP9) (TUCAN) [Cleaved into: Caspase recruitment domain-containing protein 8, C-terminus (CARD8-CT); Caspase recruitment domain-containing protein 8, N-terminus (CARD8-NT)]
Gene: CARD8

Interactor 2: CARD8 (Q9Y2G2)
Caspase recruitment domain-containing protein 8 (EC 3.4.-.-) (CARD-inhibitor of NF-kappa-B-activating ligand) (CARDINAL) (Tumor up-regulated CARD-containing antagonist of CASP9) (TUCAN) [Cleaved into: Caspase recruitment domain-containing protein 8, C-terminus (CARD8-CT); Caspase recruitment domain-containing protein 8, N-terminus (CARD8-NT)]
Gene: CARD8

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.876

Property	Details
Experiments	19337385, 11408476, 28137891, 12067710
Identification Methods	two hybrid, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CARD~CARD, FIIND~FIIND
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008233 - peptidase activity and 24 others more... GO:0008656 - cysteine-type endopeptidase activator activity involved in apoptotic process GO:0010804 - negative regulation of tumor necrosis factor-mediated signaling pathway GO:0031665 - negative regulation of lipopolysaccharide-mediated signaling pathway GO:0032088 - negative regulation of NF-kappaB transcription factor activity GO:0032089 - NACHT domain binding GO:0032691 - negative regulation of interleukin-1 beta production GO:0032731 - positive regulation of interleukin-1 beta production GO:0032991 - protein-containing complex GO:0038187 - pattern recognition receptor activity GO:0042803 - protein homodimerization activity GO:0042981 - regulation of apoptotic process GO:0043122 - regulation of canonical NF-kappaB signal transduction GO:0043124 - negative regulation of canonical NF-kappaB signal transduction GO:0043280 - positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0050700 - CARD domain binding GO:0051607 - defense response to virus GO:0072559 - NLRP3 inflammasome complex GO:0097264 - self proteolysis GO:0097340 - inhibition of cysteine-type endopeptidase activity GO:0140374 - antiviral innate immune response GO:0140608 - cysteine-type endopeptidase activator activity GO:0140633 - CARD8 inflammasome complex assembly GO:0140693 - molecular condensate scaffold activity GO:1900226 - negative regulation of NLRP3 inflammasome complex assembly
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	537
Hs

1	537

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Last updated: 15 Jul 2024