HitPredict

Interactor 1: UB2D4 (Q9Y2X8)
Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4)
Gene: UBE2D4

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_2
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0070534 - protein K63-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 522
+	Hs
		849315 UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		849318 UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84		TRAF3_HUMAN (19-501): 9.91e-86: 277: 22.18
+	Hs
		1052807 UB2D4_HUMAN (1-147): 8.89e-84: 243: 100.00		TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61
+	Hs
		849330 UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84		TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61
+	Hs
		584907 UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84		RO52_HUMAN (64-403): 5.77e-45: 166: 14.97
+	Hs
		301690 UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		537142 UB2D4_HUMAN (1-147): 8.89e-84: 243: 100.00		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		1377469 UB2D4_HUMAN (1-147): 8.89e-84: 243: 100.00		TRI17_HUMAN (58-408): 7.59e-43: 160: 11.86
+	Hs
		536760 UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		1313765 UB2D4_HUMAN (1-147): 8.89e-84: 243: 100.00		TRI62_HUMAN (63-357): 2.01e-40: 153: 16.17
+	Hs
		1204911 UB2D4_HUMAN (1-147): 8.89e-84: 243: 100.00		TRI50_HUMAN (60-403): 1.01e-39: 152: 14.12
+	Hs
		1318719 UB2D4_HUMAN (1-147): 8.89e-84: 243: 100.00		TRIM5_HUMAN (56-315): 8.46e-38: 147: 16.11
+	Hs
		849314 UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84		TRI26_HUMAN (61-410): 2.85e-38: 149: 14.59
+	Hs
		1318532 UB2D4_HUMAN (1-147): 8.89e-84: 243: 100.00		TRI31_HUMAN (58-334): 3.02e-35: 138: 15.00
+	Hs
		1377468 UB2D4_HUMAN (1-147): 8.89e-84: 243: 100.00		RN114_HUMAN (63-232): 4.73e-33: 127: 19.13
+	Hs
		1163056 UB2D4_HUMAN (1-147): 8.89e-84: 243: 100.00		TRAF7_HUMAN (60-208): 5.13e-18: 89.5: 23.26
+	Mm
		895982 UB2D1_MOUSE (1-147): 4.61e-83: 241: 91.84		RNF41_MOUSE (55-177): 2.68e-17: 84.9: 33.33
+	Hs
		1283434 UB2D4_HUMAN (1-147): 8.89e-84: 243: 100.00		RN166_HUMAN (61-222): 7.37e-16: 79.1: 22.94
+	Hs
		1252560 UB2D4_HUMAN (1-147): 8.89e-84: 243: 100.00		LNX1_HUMAN (58-183): 2.59e-11: 68.3: 19.84
+	Hs
		1290204 UB2D4_HUMAN (1-147): 8.89e-84: 243: 100.00		RN125_HUMAN (62-193): 1.59e-11: 66: 25.83