HitPredict

Interactor 1: HCN4 (Q9Y3Q4)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Gene: HCN4

Interactor 2: HCN4 (Q9Y3Q4)
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Gene: HCN4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.65 1.00 0.812

The method score is based on:

Property Details
Experiments 24776929, 22006928
Identification Methods x-ray crystallography, molecular sieving, cosedimentation in solution, dynamic light scattering
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains cNMP_binding~cNMP_binding, Ion_trans~cNMP_binding, Ion_trans_N~cNMP_binding, Ion_trans~Ion_trans, Ion_trans~Ion_trans_N
Common GO terms GO:0002027 - regulation of heart rate
GO:0003163 - sinoatrial node development
GO:0003254 - regulation of membrane depolarization
GO:0005222 - intracellularly cAMP-activated cation channel activity
GO:0005248 - voltage-gated sodium channel activity
and 24 others

more...
Homologous interactions 13

Homologous interactions

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024