HitPredict

Interactor 1: T22D4 (Q9Y3Q8)
TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2)
Gene: TSC22D4

Interactor 2: WNK2 (Q9Y3S1)
Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43)
Gene: WNK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 395 Hs			1 2297
+	Hs
		1330751 T22D4_HUMAN (1-395): 1.5e-63: 210: 100.00		WNK1_HUMAN (38-2278): 6.16e-123: 437: 26.17
+	Hs
		1077338 T22D1_HUMAN (28-394): 4.95e-38: 148: 26.81		WNK1_HUMAN (38-2278): 6.16e-123: 437: 26.17
+	Rn
		914592 T22D1_RAT (28-394): 4.07e-36: 142: 27.59		AKT3_RAT (138-520): 1.07e-122: 398: 18.53
+	Hs
		1317207 T22D4_HUMAN (1-395): 1.5e-63: 210: 100.00		WNK3_HUMAN (1005-2172): 8.57e-61: 234: 15.52
+	Hs
		320553 TITIN_HUMAN (5-287): 1.18e-10: 65.7: 11.75		OXSR1_HUMAN (180-622): 7.14e-107: 355: 24.41
+	Hs
		256827 T22D2_HUMAN (23-388): 4.37e-28: 118: 27.69		WNK3_HUMAN (1005-2172): 8.57e-61: 234: 15.52
+	Hs
		1355633 T22D4_HUMAN (1-395): 1.5e-63: 210: 100.00		NRBP_HUMAN (208-455): 1.63e-27: 121: 34.77
+	Hs
		1345645 T22D4_HUMAN (1-395): 1.5e-63: 210: 100.00		NRBP2_HUMAN (192-455): 3.09e-26: 117: 30.50
+	Hs
		1217314 Q8IV54_HUMAN (1-310): 5.68e-44: 156: 99.68		NRBP_HUMAN (208-455): 1.63e-27: 121: 34.77
+	Hs
		1077357 T22D1_HUMAN (28-394): 4.95e-38: 148: 26.81		NRBP_HUMAN (208-455): 1.63e-27: 121: 34.77
+	Hs
		1077348 T22D1_HUMAN (28-394): 4.95e-38: 148: 26.81		NRBP2_HUMAN (192-455): 3.09e-26: 117: 30.50
+	Hs
		256836 T22D2_HUMAN (23-388): 4.37e-28: 118: 27.69		NRBP_HUMAN (208-455): 1.63e-27: 121: 34.77
+	Hs
		256831 T22D2_HUMAN (23-388): 4.37e-28: 118: 27.69		NRBP2_HUMAN (192-455): 3.09e-26: 117: 30.50
+	Hs
		1304682 T22D3_HUMAN (276-395): 2.33e-27: 107: 49.59		NRBP_HUMAN (208-455): 1.63e-27: 121: 34.77
+	Hs
		1304681 T22D3_HUMAN (276-395): 2.33e-27: 107: 49.59		NRBP2_HUMAN (192-455): 3.09e-26: 117: 30.50
+	Dm
		1098027 BUN2_DROME (139-390): 4.04e-11: 66.9: 26.92		NRBP_DROME (100-455): 2.86e-27: 122: 31.02
+	Dm
		113976 M9PB30_DROME (17-393): 2.17e-11: 68: 13.52		M9PB30_DROME (1253-1923): 7.23e-23: 110: 14.56
+	Hs
		851712 WHRN_HUMAN (9-315): 6.95e-10: 63: 13.14		NEK4_HUMAN (225-460): 3.04e-22: 107: 31.45