HitPredict

Interactor 1: SAMH1 (Q9Y3Z3)
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) (SAM domain and HD domain-containing protein 1) (hSAMHD1)
Gene: SAMHD1

Interactor 2: SAMH1 (Q9Y3Z3)
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (dNTPase) (EC 3.1.5.-) (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5) (SAM domain and HD domain-containing protein 1) (hSAMHD1)
Gene: SAMHD1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 0.90 0.862

The method score is based on:

Property Details
Experiments 25423367, 24753578, 22056990, 24141705
Identification Methods two hybrid, cosedimentation in solution, protein cross-linking with a bifunctional reagent, molecular sieving, x-ray crystallography, light scattering
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains HD~HD, HD~SAM_2, SAM_2~SAM_2
Common GO terms GO:0000724 - double-strand break repair via homologous recombination
GO:0003676 - nucleic acid binding
GO:0003697 - single-stranded DNA binding
GO:0003723 - RNA binding
GO:0004540 - RNA nuclease activity
and 23 others

more...
Homologous interactions 0

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024