HitPredict

Interactor 1: VPP2 (Q9Y487)
V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2)
Gene: ATP6V0A2

Interactor 2: VATD (Q9Y5K8)
V-type proton ATPase subunit D (V-ATPase subunit D) (V-ATPase 28 kDa accessory protein) (Vacuolar proton pump subunit D)
Gene: ATP6V1D

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

The method score is based on:

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane GO:0005765 - lysosomal membrane GO:0005886 - plasma membrane GO:0007035 - vacuolar acidification GO:0010008 - endosome membrane and 6 others more... GO:0016241 - regulation of macroautophagy GO:0033176 - proton-transporting V-type ATPase complex GO:0046961 - proton-transporting ATPase activity, rotational mechanism GO:0061795 - Golgi lumen acidification GO:1902495 - transmembrane transporter complex GO:1902600 - proton transmembrane transport
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1	856
Hs

1	247

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024