HitPredict

Interactor 1: UBP15 (Q9Y4E8)
Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Unph-2) (Unph4)
Gene: USP15

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	31903660, 20622874
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 981 Hs			1 522
+	Hs
		1024451 UBP4_HUMAN (1-981): 0: 794: 55.38		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Mm
		715072 UBP4_MOUSE (1-981): 0: 802: 55.72		TRAF6_MOUSE (1-522): 5.7e-141: 418: 87.93
+	Hs
		1313391 UBP15_HUMAN (1-981): 0: 859: 100.00		TRAF4_HUMAN (54-500): 6.36e-91: 287: 26.11
+	Hs
		1020630 UBP4_HUMAN (1-981): 0: 794: 55.38		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		1290911 UBP15_HUMAN (1-981): 0: 859: 100.00		TRI11_HUMAN (59-404): 1.13e-49: 179: 12.75
+	Hs
		1052814 UBP15_HUMAN (1-981): 0: 859: 100.00		TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61
+	Hs
		585101 UBP15_HUMAN (1-981): 0: 859: 100.00		RO52_HUMAN (64-403): 5.77e-45: 166: 14.97
+	Hs
		537147 UBP15_HUMAN (1-981): 0: 859: 100.00		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		1377848 UBP15_HUMAN (1-981): 0: 859: 100.00		TRI17_HUMAN (58-408): 7.59e-43: 160: 11.86
+	Hs
		1318721 UBP15_HUMAN (1-981): 0: 859: 100.00		TRIM5_HUMAN (56-315): 8.46e-38: 147: 16.11
+	Hs
		1024331 UBP4_HUMAN (1-981): 0: 794: 55.38		TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61
+	Hs
		584941 UBP4_HUMAN (1-981): 0: 794: 55.38		RO52_HUMAN (64-403): 5.77e-45: 166: 14.97
+	Rn
		88506 UBP11_RAT (8-956): 0: 675: 43.74		D3Z9G0_RAT (20-501): 1.11e-86: 280: 22.40
+	Hs
		301460 UBP19_HUMAN (197-960): 5.82e-149: 477: 29.50		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		536761 UBP11_HUMAN (9-946): 0: 661: 43.58		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		1020756 UBP31_HUMAN (287-937): 1.96e-116: 390: 26.28		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		1356323 UBP21_HUMAN (570-935): 1.17e-66: 236: 20.32		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		301359 UBP19_HUMAN (197-960): 5.82e-149: 477: 29.50		RO52_HUMAN (64-403): 5.77e-45: 166: 14.97
+	Hs
		1198275 UBP37_HUMAN (126-958): 3.63e-87: 302: 14.10		TRIM4_HUMAN (61-336): 6.36e-43: 161: 12.90
+	Hs
		1318717 UBP21_HUMAN (570-935): 1.17e-66: 236: 20.32		TRIM5_HUMAN (56-315): 8.46e-38: 147: 16.11