Interactor 1: RIPK3 (Q9Y572)
Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3)
Gene: RIPK3

Interactor 2: RIPK3 (Q9Y572)
Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3)
Gene: RIPK3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 1.00 0.906

The method score is based on:

Property Details
Experiments 27045108, 19524513, 14743216, 22817896
Identification Methods enzymatic study, protein kinase assay, tandem affinity purification, molecular sieving, electron microscopy, fluorescence technology, circular dichroism
Interaction Type direct interaction, phosphorylation reaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase, RHIM~RHIM
Common GO terms GO:0001914 - regulation of T cell mediated cytotoxicity
GO:0002819 - regulation of adaptive immune response
GO:0003713 - transcription coactivator activity
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
and 36 others

more...

Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 518
Hs

1 518
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+ Hs
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024