HitPredict

Interactor 1: PCDA9 (Q9Y5H5)
Protocadherin alpha-9 (PCDH-alpha-9)
Gene: PCDHA9

Interactor 2: PCDAA (Q9Y5I2)
Protocadherin alpha-10 (PCDH-alpha-10)
Gene: PCDHA10

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cadherin~Cadherin, Cadherin~Cadherin_2
Common GO terms	GO:0005509 - calcium ion binding GO:0005886 - plasma membrane GO:0007155 - cell adhesion GO:0007156 - homophilic cell adhesion via plasma membrane adhesion molecules GO:0007399 - nervous system development
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 950 Hs			1 948
+	Hs
		1378063 PCDAD_HUMAN (1-950): 0: 1078: 80.95		PCDAA_HUMAN (1-948): 0: 1058: 100.00
+	Hs
		1378062 PCDA2_HUMAN (1-950): 0: 1074: 79.90		PCDAA_HUMAN (1-948): 0: 1058: 100.00
+	Hs
		1357418 PCDA4_HUMAN (1-950): 0: 1073: 84.42		PCDAA_HUMAN (1-948): 0: 1058: 100.00
+	Hs
		1378060 PCDA3_HUMAN (1-950): 0: 1073: 82.63		PCDAA_HUMAN (1-948): 0: 1058: 100.00
+	Hs
		1357387 PCDA4_HUMAN (1-950): 0: 1073: 84.42		PCDGK_HUMAN (26-896): 0: 1010: 38.57
+	Hs
		1377996 PCDA3_HUMAN (1-950): 0: 1073: 82.63		PCDGL_HUMAN (16-896): 0: 987: 37.24
+	Hs
		1378053 PCDAD_HUMAN (1-950): 0: 1078: 80.95		PCDA8_HUMAN (1-595): 2.46e-124: 402: 23.13
+	Hs
		1378052 PCDA2_HUMAN (1-950): 0: 1074: 79.90		PCDA8_HUMAN (1-595): 2.46e-124: 402: 23.13
+	Hs
		1357416 PCDA4_HUMAN (1-950): 0: 1073: 84.42		PCDA8_HUMAN (1-595): 2.46e-124: 402: 23.13
+	Hs
		1357417 PCDA4_HUMAN (1-950): 0: 1073: 84.42		PCDAB_HUMAN (1-594): 2.51e-124: 402: 23.38
+	Hs
		1378051 PCDA3_HUMAN (1-950): 0: 1073: 82.63		PCDA8_HUMAN (1-595): 2.46e-124: 402: 23.13
+	Hs
		1378059 PCDA3_HUMAN (1-950): 0: 1073: 82.63		PCDAB_HUMAN (1-594): 2.51e-124: 402: 23.38
+	Hs
		1357407 PCDA2_HUMAN (1-950): 0: 1074: 79.90		PCDA7_HUMAN (1-595): 6.73e-124: 400: 23.62
+	Hs
		1357403 PCDA4_HUMAN (1-950): 0: 1073: 84.42		PCDA7_HUMAN (1-595): 6.73e-124: 400: 23.62
+	Hs
		1357410 PCDA3_HUMAN (1-950): 0: 1073: 82.63		PCDA6_HUMAN (1-595): 8.25e-124: 400: 24.06
+	Hs
		1378061 PCDA3_HUMAN (1-950): 0: 1073: 82.63		PCDA1_HUMAN (1-595): 1.71e-123: 400: 23.13
+	Hs
		1357414 PCDA4_HUMAN (1-950): 0: 1073: 84.42		PCDGA_HUMAN (1-579): 7.52e-122: 395: 24.04
+	Hs
		1357412 PCDA4_HUMAN (1-950): 0: 1073: 84.42		PCDAC_HUMAN (1-595): 1.15e-118: 386: 23.66
+	Hs
		1357415 PCDA4_HUMAN (1-950): 0: 1073: 84.42		PCDA9_HUMAN (1-595): 1.45e-116: 381: 23.29
+	Hs
		1378047 PCDA3_HUMAN (1-950): 0: 1073: 82.63		PCDA9_HUMAN (1-595): 1.45e-116: 381: 23.29