HitPredict

Interactor 1: PCDA5 (Q9Y5H7)
Protocadherin alpha-5 (PCDH-alpha-5)
Gene: PCDHA5

Interactor 2: PCDAA (Q9Y5I2)
Protocadherin alpha-10 (PCDH-alpha-10)
Gene: PCDHA10

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cadherin~Cadherin, Cadherin~Cadherin_2
Common GO terms	GO:0005509 - calcium ion binding GO:0005886 - plasma membrane GO:0007155 - cell adhesion GO:0007156 - homophilic cell adhesion via plasma membrane adhesion molecules GO:0007399 - nervous system development
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 936 Hs			1 948
+	Hs
		1357418 PCDA4_HUMAN (1-936): 0: 1042: 82.89		PCDAA_HUMAN (1-948): 0: 1058: 100.00
+	Hs
		1378064 PCDAB_HUMAN (23-936): 0: 1037: 80.91		PCDAA_HUMAN (1-948): 0: 1058: 100.00
+	Hs
		1357387 PCDA4_HUMAN (1-936): 0: 1042: 82.89		PCDGK_HUMAN (26-896): 0: 1010: 38.57
+	Hs
		1378066 PCDAB_HUMAN (23-936): 0: 1037: 80.91		PCDC2_HUMAN (1-556): 2.36e-127: 411: 23.26
+	Hs
		1357416 PCDA4_HUMAN (1-936): 0: 1042: 82.89		PCDA8_HUMAN (1-595): 2.46e-124: 402: 23.13
+	Hs
		1357417 PCDA4_HUMAN (1-936): 0: 1042: 82.89		PCDAB_HUMAN (1-594): 2.51e-124: 402: 23.38
+	Hs
		1357403 PCDA4_HUMAN (1-936): 0: 1042: 82.89		PCDA7_HUMAN (1-595): 6.73e-124: 400: 23.62
+	Hs
		1357419 PCDA4_HUMAN (1-936): 0: 1042: 82.89		PCDA1_HUMAN (1-595): 1.71e-123: 400: 23.13
+	Hs
		1357414 PCDA4_HUMAN (1-936): 0: 1042: 82.89		PCDGA_HUMAN (1-579): 7.52e-122: 395: 24.04
+	Hs
		1378065 PCDAB_HUMAN (23-936): 0: 1037: 80.91		PCDA1_HUMAN (1-595): 1.71e-123: 400: 23.13
+	Hs
		1378055 PCDA1_HUMAN (24-936): 0: 1032: 81.97		PCDA8_HUMAN (1-595): 2.46e-124: 402: 23.13
+	Hs
		1378046 PCDAB_HUMAN (23-936): 0: 1037: 80.91		PCDGA_HUMAN (1-579): 7.52e-122: 395: 24.04
+	Hs
		1357412 PCDA4_HUMAN (1-936): 0: 1042: 82.89		PCDAC_HUMAN (1-595): 1.15e-118: 386: 23.66
+	Hs
		1378059 PCDAB_HUMAN (23-936): 0: 1037: 80.91		PCDA3_HUMAN (1-595): 2.73e-120: 391: 21.82
+	Hs
		1357415 PCDA4_HUMAN (1-936): 0: 1042: 82.89		PCDA9_HUMAN (1-595): 1.45e-116: 381: 23.29
+	Hs
		1357426 PCDAB_HUMAN (23-936): 0: 1037: 80.91		PCDAC_HUMAN (1-595): 1.15e-118: 386: 23.66
+	Hs
		1378061 PCDA1_HUMAN (24-936): 0: 1032: 81.97		PCDA3_HUMAN (1-595): 2.73e-120: 391: 21.82
+	Hs
		1378048 PCDAB_HUMAN (23-936): 0: 1037: 80.91		PCDA9_HUMAN (1-595): 1.45e-116: 381: 23.29